Metabolite details
Reactome pathways
- R-HSA-110331 - Cleavage of the damaged purine
- R-HSA-1430728 - Metabolism
- R-HSA-15869 - Metabolism of nucleotides
- R-HSA-1643685 - Disease
- R-HSA-382551 - Transport of small molecules
- R-HSA-425397 - Transport of vitamins, nucleosides, and related molecules
- R-HSA-425407 - SLC-mediated transmembrane transport
- R-HSA-5668914 - Diseases of metabolism
- R-HSA-73884 - Base Excision Repair
- R-HSA-73894 - DNA Repair
- R-HSA-73927 - Depurination
- R-HSA-73929 - Base-Excision Repair, AP Site Formation
- R-HSA-74217 - Purine salvage
- R-HSA-74259 - Purine catabolism
- R-HSA-83936 - Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
- R-HSA-8956319 - Nucleotide catabolism
- R-HSA-8956321 - Nucleotide salvage
- R-HSA-9734207 - Nucleotide salvage defects
- R-HSA-9734281 - Defective HPRT1 disrupts guanine and hypoxanthine salvage
- R-HSA-9735804 - Diseases of nucleotide metabolism
Observed in studies
- Biological effect of chronic mistranslation in mammalian cells
- Absence of tmRNA Increases the Persistence to Cefotaxime and the Intercellular Accumulation of Metabolite GlcNAc in <i>Aeromonas veronii</i>.
- Absence of tmRNA increases the persistence to cefotaxime by upregulating the metabolites GlcNAc in Aeromonas veronii
- Distribution of RESV and its metabolite peaks in mouse tissues after oral and skin administration
- Resveratrol metabolism in HepG2 (human hepatocytes), HaCaT (human keratinocytes), and C2C12 (mouse myoblasts)
- Organic Acids Modulate Systemic Metabolic Perturbation Caused by Salmonella Pullorum Challenge in Early-Stage Broilers.
- Cell-based and multi-omics profiling reveal dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei
- Hfq Regulates Efflux Pump Expression and Purine Metabolic Pathway to Increase the Trimethoprim Resistance in Aeromonas veronii
- Four layer multi-omics reveals molecular responses to aneuploidy in <i>Leishmania</i>
- Jejunal inflammatory cytokines, barrier proteins and microbiome-metabolome responses to early supplementary feeding of Bamei suckling piglets
- Functional Characterization of the Lin28/let-7 Circuit During Forelimb Regeneration in Ambystoma mexicanum and Its Influence on Metabolic Reprogramming
- Bioaccumulation of therapeutic drugs by human gut bacteria: cross-feeding metabolite analysis (FIA-MS) (E.rectale;S.salivarius assays)
- How Does the Seed Pre-germinative Metabolism Fight against Imbibition Damage; Emerging Roles of Fatty Acid Cohort and Antioxidant Defence
- Large-Scale Plasma Analysis Revealed New Mechanisms and Molecules Associated with the Host Response to SARS-CoV-2.
- Bioplatforms Australia: Antibiotic Resistant Sepsis Pathogens Framework Initiative (Escherichia coli assays)
- Human age-declined saliva metabolic markers determined by LC-MS
- Metabolic Dynamics of In Vitro CD8+ T Cell Activation.
- Global analysis of plasma lipidomics reveals altered lipid signatures in patients with osteonecrosis of the femoral head
- Metabolomic profiling reveals the effects of early-life lactoferrin intervention on protein synthesis, energy production and antioxidative capacity in the liver of suckling piglets
- Model-driven multi-omic data analysis elucidates metabolic immunomodulators of macrophage activation
- Bioplatforms Australia: Antibiotic Resistant Sepsis Pathogens Framework Initiative (Klebsiella pneumoniae assays)
- Bioplatforms Australia: Antibiotic Resistant Sepsis Pathogens Framework Initiative (Streptococcus pneumoniae assays)
- Multi-Omics Analysis Reveals Disturbance of Nanosecond Pulsed Electric Field in the Serum Metabolic Spectrum and Gut Microbiota
- Transcriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole
- Host autophagy mediates organ wasting and nutrient mobilization for tumor growth.
- Dietary carbohydrate and protein levels affect the growth performance of juvenile peanut worm (Sipunculus nudus): an LC–MS-based metabolomics study
- Changes and correlations of intestinal flora and liver metabolite profiles in mice with gallstones
- Anti-anemia drug FG4592 retards the AKI to CKD transition by improving vascular regeneration and anti-oxidative capability (day 21)
- Anti-anemia drug FG4592 retards the AKI to CKD transition by improving vascular regeneration and anti-oxidative capability (day 10)
- Jasmonate-mediated stomatal closure under elevated CO2 revealed by time-resolved metabolomics
- The gut microbiome and metabolites are altered and interrelated in patients with rheumatoid arthritis
- Multiple biochemical indices and metabolomics of Clonorchis sinensis provide a novel interpretation of biomarkers
- Metabolite profile data of grapevine plants with brown wood streaking and grapevine leaf stripe (esca complex disease) symptoms
- Analysis of Growth Phases of Enterotoxigenic Escherichia coli Reveals a Distinct Transition Phase before Entry into Early Stationary Phase with Shifts in Tryptophan, Fucose, and Putrescine Metabolism and Degradation of Neurotransmitter Precursors
- Metabolic plasticity confers increased resilience to climate variability in temperate compared to tropical lizards
- Distinct succinate modifying products are clinically diagnostic and prognostic biomarkers for fumarate hydratase deficient renal cell carcinoma
- Gut microbiome drives individual memory variation in bumblebees
- The Manchurian Walnut Genome: Insights into Juglone and Lipid Biosynthesis.
- Diallyl disulfide (DADS) ameliorates intestinal Candida albicans infection by modulating the gut microbiota and metabolites and providing intestinal protection in mice
- Appropriate taxonomic classification of intestinal microbiome by 16S rRNA gene targeting metagenomic approach
- Exercise-generated β-aminoisobutyric acid (BAIBA) reduces cardiomyocytes metabolic stress and apoptosis caused by mitochondrial dysfunction through the miR-208b/AMPK pathway
- Metabolic profilings of rat INS-1 β-cells under changing levels of essential amino acids
- Transcriptional Shift and Metabolic Adaptations during Leishmania Quiescence Using Stationary Phase and Drug Pressure as Models
- Transcriptome and Metabolome Analyses Reveal Differences in Terpenoid and Flavonoid Biosynthesis in Cryptomeria fortunei Needles Across Different Seasons
- Effects of Radiofrequency Field from 5G Communications on fecal microbiome and metabolome profiles in mice
- Homeostasis of the biosynthetic E. coli metabolome
- Phosphoproteomic and Metabolomic Profiling Uncovers the Roles of CcPmk1 in the Pathogenicity of <i>Cytospora chrysosperma</i>
- Integrated metabolomics and transcriptome revealed the effect of fermented Lycium barbarum residue promoting Ovis aries immunity
- Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors
- Integrated Metabolomics and Transcriptomics Analyses Reveal Anthocyanin and Carotenoid Biosynthesis Involved in Color Development in Willow Bark
- Intergenerational Association of Gut Microbiota and Metabolism between Perinatal Folic Acid Metabolism and Neural Tube Defects (Feces metabolomics)
- Intergenerational Association of Gut Microbiota and Metabolism between Perinatal Folic Acid Metabolism and Neural Tube Defects (Brain tissue metabolomics)
- Sodium Butyrate mediates Histone Crotonylation and Alleviated Neonatal Rats Hypoxic-Ischemic Brain Injury Through Gut-Brain Axis (untargeted fecal metabolomics)
- Interaction between Cervical Microbiota and Host Gene Regulation in Caesarean Section Scar Diverticulum
- Mechanism of interventional effect and targets of Zhuyu Pill in regulating and suppressing colitis and cholestasis
- Multiomic analysis revealed the potential role of rumen microbes in heat stress
- Effect of heat stress on serum enzyme activity, antioxidant capacity and immune parameter metabolomics datasets in Holstein cows at different growth stages
- Effects of Centella asiatica extract on antioxidant status and liver metabolome of rotenone-treated rats using GC-MS
- Stage-specific roles of microbial dysbiosis and metabolic disorders in rheumatoid arthritis
- PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis.
- Alterations in the gut microbiota and metabolomics of seafarers after a six-month sea voyage
- Bile acid is a significant host factor shaping the gut microbiome of diet induced obese mice (untargeted metabolome profile assay)
- Integrated Proteomic and Metabolomic Analyses Show Differential Effects of Glucose Availability in Marine <i>Synechococcus</i> and <i>Prochlorococcus</i>.
- Diverse metabolic reactions activated during 58-hr fasting are revealed by non-targeted metabolomic analysis of human blood.
- Metabolic disorder and intestinal microflora dysbiosis in chronic inflammatory demyelinating polyradiculoneuropathy
- 4-Octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING
- DNA-PKcs drives CKD progression by activating TAF7/RAPTOR/mTORC1 signaling-mediated metabolic reprogramming
- Flow cytometry has a significant impact on the cellular metabolome (General LC-MS assay)
- Flow cytometry has a significant impact on the cellular metabolome (CE-MS assay)
- GABA regulates IL-1β production in macrophages
- FSCN1 as a new druggable target in adrenocortical carcinoma
- Transcriptomics and metabolomics analysis reveal the anti-oxidation and immune boosting effects of mulberry leaves in growing mutton sheep
- Comparative metabolomic analysis of exudates of microcystin-producing and microcystin-free Microcystis aeruginosa strains
- Extracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness
- PatA mediates biofilm formation and drugs resistance through regulating the synthesis of glycolipids and lipids in mycobacterium PatA mediates a novel mycolic acid synthesis pathway and regulates biofilm formation in mycobacterium
- Metabolic changes associated with tick-microbe interactions
- TGF-β uncouples glycolysis and inflammation in macrophages and controls the survival during sepsis
- Unraveling the metabolic effects of benzophenone-3 on the endosymbiotic dinoflagellate Cladocopium goreaui
- Genetic mapping and molecular mechanism behind color variation in the Asian vine snake
- Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
- Disturbed Microbiota-Metabolites-Immune Interaction Network is Associated with Olfactory Dysfunction in Patients with Chronic Rhinosinusitis
- L-leucine increases the sensitivity of drug-resistant Salmonella to sarafloxacin by stimulating central carbon metabolism and increasing intracellular reactive oxygen species level (LC-MS positive mode)
- L-leucine increases the sensitivity of drug-resistant Salmonella to sarafloxacin by stimulating central carbon metabolism and increasing intracellular reactive oxygen species level (LC-MS negative mode)
- Metabolic effects of an aspartate aminotransferase-inhibitor on two T-cell lines
- Integrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRα deficiency.
- Inhibition of glycolysis and mitochondrial respiration promotes radiosensitisation of neuroblastoma and glioma cells
- Unexpected similarities between the Schizosaccharomyces and human blood metabolomes, and novel human metabolites (Blood fraction)
- Unexpected similarities between the Schizosaccharomyces and human blood metabolomes, and novel human metabolites (Blood plasma and RBC fractions)
- Novel Minor Groove Binders cure animal African trypanosomiasis in an in vivo mouse model
Observed in differential profiles
- rps2_wildtype_vs_rps2_A226Y
- Wild_Type_vs_tmRNA_Deletion
- Wild_Type_vs_tmRNA_Knockout
- Wild_Type_vs_tmRNA_Knockout
- Control_Oral_Blood_vs_RESV_Oral_Blood
- Control_Oral_Blood_vs_RESV_Oral_Blood
- Non-challenged_Control_vs_Challenged_Control
- HepG2_0uM_vs_HepG2_200uM
- HepG2_0uM_vs_HepG2_200uM
- HepG2_0uM_vs_HepG2_200uM
- HepG2_0uM_vs_HepG2_200uM
- HepG2_0uM_vs_HepG2_200uM
- HepG2_0uM_vs_HepG2_200uM
- Non_Induced_0_Day_vs_Induced_8_Day
- Non_Induced_0_Day_vs_Induced_8_Day
- Wild_type_vs_hfq
- Nepalese_BPK173_vs_Nepalese_BPK178
- Supplementary_feeding_vs_Control
- Uninjured_limb_vs_Late_digits_limb_growth
- G4_Eubacterium_rectale_DMSO_30_vs_G3_Eubacterium_rectale_Duloxetine_47
- Dry_Seed_vs_8h_Imbibed_Seed
- non_COVID_19_healthy_vs_non_critical_COVID_19
- RPMI_B36_vs_Pooled_Sera_B36
- RPMI_B36_vs_Pooled_Sera_B36
- Old_vs_Young
- G3_Experimental_Sample_0h_vs_G11_Experimental_Sample_96h
- G3_Experimental_Sample_0h_vs_G11_Experimental_Sample_96h
- G3_Experimental_Sample_0h_vs_G11_Experimental_Sample_96h
- G3_Experimental_Sample_0h_vs_G11_Experimental_Sample_96h
- Control_vs_AONFH_Stage_III_IV
- Control_Day_8_vs_Lactoferrin_Day_8
- G1_Klebsiella_pneumoniae_AJ218_RPMI_vs_G2_Klebsiella_pneumoniae_AJ218_Pooled_sera
- G1_Pooled_Sera_Blood_4559_vs_G2_RPMI_Glucose_Blood_4559
- Control_vs_Lipopolysaccharide_stimulated
- Control_vs_nsPEF_7_day
- WT_vs_WT_Aco
- G1_Frt_Ctrl_Day_6_vs_G3_Rasv12_Scrib_Day_6
- Diet_D2_vs_Diet_D5
- Control_vs_Lithogenic_Diet
- Sham_vs_UIR
- Sham_vs_UIR
- 400ppm_0min_vs_800ppm_60min
- Rheumatoid_Arthritis_vs_Healthy_Control
- Control_14dpi_vs_Infected_14dpi
- Control_14dpi_vs_Infected_14dpi
- Control_vs_Asymptomatic
- E1777_Intracellular_MidLog_vs_E1777_Intracellular_EarlyStationary
- T_septentrionalis_cold_vs_T_septentrionalis_warm
- Normal_control_no_tumor_vs_FH_deficient_RCC
- Hindgut_Control_vs_Lactobacillus_apis
- Embryo_S1_vs_Embryo_S4
- G1_PBS_vs_G2_DSS
- Untreated_vs_Antibiotic_Treated
- Untreated_vs_Antibiotic_Treated
- Sham_vs_Heart_Failure_Sedentary
- Sham_vs_Heart_Failure_Sedentary
- G1_Control_vs_G2_Arginine_Addition
- AMAD_Log_vs_AMAE_Sta
- Summer_vs_Winter
- Sham_vs_Radiofrequency
- Glu_BW25113_vs_Pyr_BW25113
- CcPmk1_vs_Wild_type
- RCON_vs_RFW
- Wild_Type_vs_Gene_Knockout
- Purple_vs_Green
- Normal_vs_Neural_Tube_Defect
- Normal_vs_Neural_Tube_Defect
- Normal_vs_Neural_Tube_Defect
- Sham_vs_HIBD
- Control_vs_CSD
- Control_vs_ZYP_High_Dose
- Dc-N_vs_Dc-HS
- Dcs_N_vs_Dcs_HS
- Control_vs_Treatment
- Healthy_vs_RAS4
- Healthy_vs_RAS4
- Control_0d_vs_Treatment_180d
- Control_0d_vs_Treatment_180d
- MCF-7_WT_vs_MCF-7_PKM2_KO
- Normal_Diet_vs_High-fat_Diet
- Normal_Diet_vs_High-fat_Diet
- Normal_Diet_vs_High-fat_Diet
- SS120_Control_vs_SS120_5mM
- SS120_Control_vs_SS120_5mM
- SS120_Control_vs_SS120_5mM
- SS120_Control_vs_SS120_5mM
- SS120_Control_vs_SS120_5mM
- SS120_Control_vs_SS120_5mM
- Blood_10h_vs_Blood_58h
- CIDP_patient_vs_healthy_control
- CIDP_patient_vs_healthy_control
- Control_vs_DMXAA16h
- DNA-PK_KO_UUO_vs_DNA-PK_KO_Control
- Ctrl_vs_Ab
- Control_0h_vs_GABA_0h
- Ctrl_vs_Ab
- Control_Vehicle_vs_FSCN1_Knockout_Vehicle
- Control_vs_Fermented_Mulberry_Leaves
- MC-producing_Exponential_vs_MC-free_Exponential
- MC-producing_Exponential_vs_MC-free_Exponential
- Control_vs_Lactic_Acid
- wild_type_vs_patA_deletion
- Uninfected_1h_vs_Anaplasma_phagocytophilum_1h
- Control_vs_TGF-beta_Treatment
- Control_vs_BP3_Low_Concentration
- Yellow_Skin_vs_Green_Skin
- Arginine_Replenished_Ctrl_vs_Arginine_Starved_48h
- Normal_vs_Abnormal
- Normal_vs_Abnormal
- SAR-S_vs_SAR-R
- SAR-R_vs_SAR-S
- JURKAT_Control_vs_JURKAT_Treatment
- WT_vs_ErbB2_KI
- G1_Untreated_Control_vs_G2_2DG
- Human_Blood_vs_Human_Plasma
- Human_Blood_vs_Human_Plasma
- Human_Blood_vs_Human_Plasma
- MGB234_Treatment_vs_DMSO_Control
- MGB234_Treatment_vs_DMSO_Control
- Blood_vs_Plasma
- Blood_vs_Plasma