Transcriptional Shift and Metabolic Adaptations during Leishmania Quiescence Using Stationary Phase and Drug Pressure as Models

Study details

Source ID

https://identifiers.org/metabolights:MTBLS4046

Title

Transcriptional Shift and Metabolic Adaptations during Leishmania Quiescence Using Stationary Phase and Drug Pressure as Models

Summary

Leishmania quiescence transcriptional and metabolic adaptations studied.

Observation

Transcriptome and metabolome of Leishmania promastigotes and amastigotes under quiescence.

Findings

Quiescent cells show reduced transcription and metabolism; some transcripts and metabolites are upregulated.

Disease terms

infectious disease, Leishmania

Gene terms

GP63

Chemical terms

glucose, carbon

Organisms

Leishmania

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS4046.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0008152",
    "https://identifiers.org/GO:0072690",
    "https://identifiers.org/GO:0009058",
    "https://identifiers.org/GO:0044838",
    "https://identifiers.org/GO:0006006",
    "https://identifiers.org/GO:0006351",
    "https://identifiers.org/GO:0006914"
  ],
  "go_kw": [
    "metabolism",
    "stationary phase",
    "biosynthesis",
    "quiescence",
    "glucose metabolism",
    "transcription",
    "autophagy"
  ],
  "integmet_study": "MTBLS4046",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D005947",
    "https://identifiers.org/mesh:D002244"
  ],
  "mesh_chemical_pubtator_kw": [
    "glucose",
    "carbon"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D003141",
    "https://identifiers.org/mesh:D007896"
  ],
  "mesh_disease_pubtator_kw": [
    "infectious disease",
    "Leishmania"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:89782"
  ],
  "mesh_gene_pubtator_kw": [
    "GP63"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:38568"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "Leishmania"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS4046",
  "study_findings": "Quiescent cells show reduced transcription and metabolism; some transcripts and metabolites are upregulated.",
  "study_observation": "Transcriptome and metabolome of Leishmania promastigotes and amastigotes under quiescence.",
  "study_summary": "Leishmania quiescence transcriptional and metabolic adaptations studied.",
  "study_title_original": "Transcriptional Shift and Metabolic Adaptations during Leishmania Quiescence Using Stationary Phase and Drug Pressure as Models"
}