Proteomic and metabolic changes in cancer cells after alternation of SHMT2 expressions

Study details

Source ID

https://identifiers.org/metabolights:MTBLS405

Title

Proteomic and metabolic changes in cancer cells after alternation of SHMT2 expressions

Summary

SHMT2 affects cancer cell proteomics and metabolomics.

Observation

Proteomic and metabolic changes in engineered HeLa cells with altered SHMT2 expression.

Findings

SHMT2 regulates redox balance; suppression affects glutaminolysis; benzoate reduces tumor growth.

Disease terms

hyperglycinemia, tumors, lung and other cancers, cancers, Cancer, tumor, cancer

Gene terms

ACOT2, GLUD1, Serine hydroxymethyltransferase 2, SHMT2

Chemical terms

Benzoate, serine, THF, glycine, tetrahydrofolate, benzoate, purine nucleotide, folate

Organisms

—

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS405.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0006541",
    "https://identifiers.org/GO:0006865",
    "https://identifiers.org/GO:0008283"
  ],
  "go_kw": [
    "glutamine metabolism",
    "amino acid transport",
    "cell proliferation"
  ],
  "integmet_study": "MTBLS405",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D001565",
    "https://identifiers.org/mesh:D012694",
    "https://identifiers.org/mesh:C030371",
    "https://identifiers.org/mesh:D005998",
    "https://identifiers.org/mesh:D011685",
    "https://identifiers.org/mesh:D005492"
  ],
  "mesh_chemical_pubtator_kw": [
    "Benzoate",
    "serine",
    "THF",
    "glycine",
    "tetrahydrofolate",
    "benzoate",
    "purine nucleotide",
    "folate"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D020158",
    "https://identifiers.org/mesh:D009369",
    "https://identifiers.org/mesh:D008175"
  ],
  "mesh_disease_pubtator_kw": [
    "hyperglycinemia",
    "tumors",
    "lung and other cancers",
    "cancers",
    "Cancer",
    "tumor",
    "cancer"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:10965",
    "https://identifiers.org/ncbigene:2746",
    "https://identifiers.org/ncbigene:6472"
  ],
  "mesh_gene_pubtator_kw": [
    "ACOT2",
    "GLUD1",
    "Serine hydroxymethyltransferase 2",
    "SHMT2"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS405",
  "study_findings": "SHMT2 regulates redox balance; suppression affects glutaminolysis; benzoate reduces tumor growth.",
  "study_observation": "Proteomic and metabolic changes in engineered HeLa cells with altered SHMT2 expression.",
  "study_summary": "SHMT2 affects cancer cell proteomics and metabolomics.",
  "study_title_original": "Proteomic and metabolic changes in cancer cells after alternation of SHMT2 expressions"
}