Novel Minor Groove Binders cure animal African trypanosomiasis in an in vivo mouse model

Study details

Source ID

https://identifiers.org/metabolights:MTBLS882

Title

Novel Minor Groove Binders cure animal African trypanosomiasis in an in vivo mouse model

Summary

S-MGBs cure AAT in mice.

Observation

Efficacy of Strathclyde MGBs against Trypanosoma species in mice.

Findings

S-MGBs cure T. congolense in mice without cross-resistance to diamidines.

Disease terms

AAT, Animal African trypanosomiasis, Animal African Trypanosomiasis

Gene terms

—

Chemical terms

diamidine, diamidines

Organisms

Mouse, mice, Trypanosoma vivax, Trypanosoma congolense

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS882.

{
  "@type": "Dataset",
  "integmet_study": "MTBLS882",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D010419"
  ],
  "mesh_chemical_pubtator_kw": [
    "diamidine",
    "diamidines"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D014353"
  ],
  "mesh_disease_pubtator_kw": [
    "AAT",
    "Animal African trypanosomiasis",
    "Animal African Trypanosomiasis"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:10090",
    "https://identifiers.org/taxonomy:5699",
    "https://identifiers.org/taxonomy:5692"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "Mouse",
    "mice",
    "Trypanosoma vivax",
    "Trypanosoma congolense"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS882",
  "study_findings": "S-MGBs cure T. congolense in mice without cross-resistance to diamidines.",
  "study_observation": "Efficacy of Strathclyde MGBs against Trypanosoma species in mice.",
  "study_summary": "S-MGBs cure AAT in mice.",
  "study_title_original": "Novel Minor Groove Binders cure animal African trypanosomiasis in an in vivo mouse model"
}