Cell-based and multi-omics profiling reveal dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei

Study details

Source ID

https://identifiers.org/metabolights:MTBLS1390

Title

Cell-based and multi-omics profiling reveal dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei

Summary

Mitochondrial metabolic changes in Trypanosoma brucei.

Observation

Mitochondrial metabolic remodeling during Trypanosoma brucei life cycle.

Findings

Mitochondria release ROS to drive cellular differentiation.

Disease terms

mitochondrial membrane

Gene terms

—

Chemical terms

proline, tricarboxylic acid, ROS, reactive oxygen species, TCA, ATP

Organisms

tsetse fly, Trypanosoma brucei

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS1390.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0010133",
    "https://identifiers.org/GO:0005739",
    "https://identifiers.org/GO:0005829",
    "https://identifiers.org/GO:0006099",
    "https://identifiers.org/GO:0006119"
  ],
  "go_kw": [
    "proline oxidation",
    "mitochondrion",
    "cytosol",
    "TCA cycle",
    "oxidative phosphorylation"
  ],
  "integmet_study": "MTBLS1390",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D011392",
    "https://identifiers.org/mesh:D014233",
    "https://identifiers.org/mesh:D017382",
    "https://identifiers.org/mesh:D000255"
  ],
  "mesh_chemical_pubtator_kw": [
    "proline",
    "tricarboxylic acid",
    "ROS",
    "reactive oxygen species",
    "TCA",
    "ATP"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D015433"
  ],
  "mesh_disease_pubtator_kw": [
    "mitochondrial membrane"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:7393",
    "https://identifiers.org/taxonomy:5691"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "tsetse fly",
    "Trypanosoma brucei"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS1390",
  "study_findings": "Mitochondria release ROS to drive cellular differentiation.",
  "study_observation": "Mitochondrial metabolic remodeling during Trypanosoma brucei life cycle.",
  "study_summary": "Mitochondrial metabolic changes in Trypanosoma brucei.",
  "study_title_original": "Cell-based and multi-omics profiling reveal dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei"
}