Bioaccumulation of therapeutic drugs by human gut bacteria: cross-feeding metabolite analysis (FIA-MS) (E.rectale;S.salivarius assays)

Study details

Source ID

https://identifiers.org/metabolights:MTBLS1792

Title

Bioaccumulation of therapeutic drugs by human gut bacteria: cross-feeding metabolite analysis (FIA-MS) (E.rectale;S.salivarius assays)

Summary

Gut bacteria bioaccumulate drugs affecting drug availability.

Observation

Depletion of 15 drugs by 25 gut bacterial strains.

Findings

70 bacteria-drug interactions; bioaccumulation affects drug availability and bacterial metabolism.

Disease terms

—

Gene terms

—

Chemical terms

duloxetine

Organisms

human, Caenorhabditis elegans

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS1792.

{
  "@type": "Dataset",
  "integmet_study": "MTBLS1792",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D000068736"
  ],
  "mesh_chemical_pubtator_kw": [
    "duloxetine"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:9606",
    "https://identifiers.org/taxonomy:6239"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "human",
    "Caenorhabditis elegans"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS1792",
  "study_findings": "70 bacteria-drug interactions; bioaccumulation affects drug availability and bacterial metabolism.",
  "study_observation": "Depletion of 15 drugs by 25 gut bacterial strains.",
  "study_summary": "Gut bacteria bioaccumulate drugs affecting drug availability.",
  "study_title_original": "Bioaccumulation of therapeutic drugs by human gut bacteria: cross-feeding metabolite analysis (FIA-MS) (E.rectale;S.salivarius assays)"
}