Inhibition of glycolysis and mitochondrial respiration promotes radiosensitisation of neuroblastoma and glioma cells

Study details

Source ID

https://identifiers.org/metabolights:MTBLS858

Title

Inhibition of glycolysis and mitochondrial respiration promotes radiosensitisation of neuroblastoma and glioma cells

Summary

Radiosensitisation of neuroblastoma and glioma cells studied.

Observation

Radiosensitising effects of glycolysis and mitochondrial inhibitors on cancer cells.

Findings

2-DG and metformin combination enhances radiosensitivity by disrupting metabolism and inducing G2/M arrest.

Disease terms

glioma, malignancies, Neuroblastoma, neuroblastoma, cancer

Gene terms

—

Chemical terms

biguanide, metformin, 2-DG, ATP

Organisms

—

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS858.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0008152",
    "https://identifiers.org/GO:0006915",
    "https://identifiers.org/GO:0006096"
  ],
  "go_kw": [
    "metabolism",
    "apoptotic cell death",
    "glycolysis"
  ],
  "integmet_study": "MTBLS858",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D001645",
    "https://identifiers.org/mesh:D008687",
    "https://identifiers.org/mesh:D003847",
    "https://identifiers.org/mesh:D000255"
  ],
  "mesh_chemical_pubtator_kw": [
    "biguanide",
    "metformin",
    "2-DG",
    "ATP"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D005910",
    "https://identifiers.org/mesh:D009369",
    "https://identifiers.org/mesh:D009447"
  ],
  "mesh_disease_pubtator_kw": [
    "glioma",
    "malignancies",
    "Neuroblastoma",
    "neuroblastoma",
    "cancer"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS858",
  "study_findings": "2-DG and metformin combination enhances radiosensitivity by disrupting metabolism and inducing G2/M arrest.",
  "study_observation": "Radiosensitising effects of glycolysis and mitochondrial inhibitors on cancer cells.",
  "study_summary": "Radiosensitisation of neuroblastoma and glioma cells studied.",
  "study_title_original": "Inhibition of glycolysis and mitochondrial respiration promotes radiosensitisation of neuroblastoma and glioma cells"
}