Diff Profiles › MTBLS533_0001_00000001

MCF-7_WT_vs_MCF-7_PKM2_KO

MCF-7_WT vs MCF-7_PKM2_KO

p-value ≤ 0.05 144 significant 2025-09-26 00:00:00 Study: MTBLS533
351 Total Features
144 Significant
0.05 p-value Threshold

Profile details

Identifier
MTBLS533_0001_00000001
Linked study
MTBLS533 — PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis.
Comparison
MCF-7_WT vs MCF-7_PKM2_KO
Group A
Wild-type MCF-7 cells. Serves as a reference for comparing genetic modifications in MCF-7 cells.
Group B
MCF-7 cells with PKM2 knockout. Helps in understanding the role of PKM2 in MCF-7 cells.
Total features tested
351
Significant features
144
p-value threshold
0.05
Ratio threshold (upper)
1.5
Ratio threshold (lower)
1/1.5
Date created
2025-09-26 00:00:00

Top hits

Metabolite ID (InChI Key) Name Direction Ratio p-value
NOTGFIUVDGNKRI-UUOKFMHZSA-N Aica ribonucleotide up 112.1 5.25e-06
KLZGKIDSEJWEDW-UHFFFAOYSA-N N-Acetylputrescine up 12.42 1.22e-07
GXIURPTVHJPJLF-UHFFFAOYSA-N 3-hydroxy-2-(phosphonooxy)propanoic acid down 0.08734 9.59e-07
GWNXFCYUJXASDX-UHFFFAOYSA-N γ-Glu-Thr up 7.335 1.05e-07
GVJHHUAWPYXKBD-IEOSBIPESA-N <i>R</i><i>R</i><i>R</i>-α-tocopherol down 0.1144 5.24e-07
OSJPPGNTCRNQQC-UHFFFAOYSA-N Glycerate 3-phosphate down 0.07842 5.44e-06
JCMUOFQHZLPHQP-BQBZGAKWSA-N N-{(2S)-1-[(carboxymethyl)amino]-1-oxobutan-2-yl}-L-glutamine up 5.156 2.65e-08
KIDHWZJUCRJVML-UHFFFAOYSA-N Butane-1,4-diamine up 4.026 3.67e-09
RGHNJXZEOKUKBD-SQOUGZDYSA-N Hexonic acid up 4.641 2.98e-07
AQAKHZVPOOGUCK-XPUUQOCRSA-N gamma-Glutamylvaline up 4.155 2.14e-07