PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis.

Study details

Source ID

https://identifiers.org/metabolights:MTBLS533

Title

PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis.

Summary

PKM2 methylation by CARM1 promotes tumorigenesis.

Observation

PKM2 methylation by CARM1 in breast cancer cells.

Findings

PKM2 methylation shifts metabolism to aerobic glycolysis, promoting tumorigenesis.

Disease terms

tumorigenesis, metastasis, cancer, breast cancer

Gene terms

CARM1, co-activator-associated arginine methyltransferase 1

Chemical terms

calcium

Organisms

—

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS533.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0005737",
    "https://identifiers.org/GO:0016310",
    "https://identifiers.org/GO:0008283",
    "https://identifiers.org/GO:0005783",
    "https://identifiers.org/GO:0005739",
    "https://identifiers.org/GO:0006119",
    "https://identifiers.org/GO:0032259",
    "https://identifiers.org/GO:0006096"
  ],
  "go_kw": [
    "cytoplasm",
    "phosphorylation",
    "cell proliferation",
    "endoplasmic reticulum",
    "mitochondria",
    "oxidative phosphorylation",
    "methylation",
    "glycolysis"
  ],
  "integmet_study": "MTBLS533",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D002118"
  ],
  "mesh_chemical_pubtator_kw": [
    "calcium"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D063646",
    "https://identifiers.org/mesh:D009362",
    "https://identifiers.org/mesh:D009369",
    "https://identifiers.org/mesh:D001943"
  ],
  "mesh_disease_pubtator_kw": [
    "tumorigenesis",
    "metastasis",
    "cancer",
    "breast cancer"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:10498"
  ],
  "mesh_gene_pubtator_kw": [
    "CARM1",
    "co-activator-associated arginine methyltransferase 1"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS533",
  "study_findings": "PKM2 methylation shifts metabolism to aerobic glycolysis, promoting tumorigenesis.",
  "study_observation": "PKM2 methylation by CARM1 in breast cancer cells.",
  "study_summary": "PKM2 methylation by CARM1 promotes tumorigenesis.",
  "study_title_original": "PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis."
}