TGF-β uncouples glycolysis and inflammation in macrophages and controls the survival during sepsis

Study details

Source ID

https://identifiers.org/metabolights:MTBLS6886

Title

TGF-β uncouples glycolysis and inflammation in macrophages and controls the survival during sepsis

Summary

TGF-β affects macrophage metabolism and sepsis survival.

Observation

Macrophage metabolism regulation and its effects on sepsis.

Findings

TGF-β regulates glycolysis and cytokine production, affecting sepsis survival.

Disease terms

septic, inflammation, blood coagulation, sepsis, COVID-19 disease, inflammatory, endotoxemia

Gene terms

transforming growth factor-beta, PFKL, phosphofructokinase-1 liver type, AP-1, TGF-beta, mTOR, F13A1, STAT1, SMAD3, NF-kappaB, TGFBRI

Chemical terms

LPS

Organisms

—

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS6886.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0006954",
    "https://identifiers.org/GO:0008152",
    "https://identifiers.org/GO:0005737",
    "https://identifiers.org/GO:0005634",
    "https://identifiers.org/GO:0001775",
    "https://identifiers.org/GO:0001816",
    "https://identifiers.org/GO:0006351",
    "https://identifiers.org/GO:0005886",
    "https://identifiers.org/GO:0031012",
    "https://identifiers.org/GO:0050817",
    "https://identifiers.org/GO:0006955",
    "https://identifiers.org/GO:0006096"
  ],
  "go_kw": [
    "inflammation",
    "metabolism",
    "cytoplasm",
    "nucleus",
    "cell activation",
    "cytokine production",
    "transcription",
    "cell membrane",
    "extracellular matrix",
    "coagulation",
    "immune response",
    "glycolysis"
  ],
  "integmet_study": "MTBLS6886",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D008070"
  ],
  "mesh_chemical_pubtator_kw": [
    "LPS"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D001170",
    "https://identifiers.org/mesh:D007249",
    "https://identifiers.org/mesh:D001778",
    "https://identifiers.org/mesh:D018805",
    "https://identifiers.org/mesh:D000086382",
    "https://identifiers.org/mesh:D019446"
  ],
  "mesh_disease_pubtator_kw": [
    "septic",
    "inflammation",
    "blood coagulation",
    "sepsis",
    "COVID-19 disease",
    "inflammatory",
    "endotoxemia"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:7040",
    "https://identifiers.org/ncbigene:5211",
    "https://identifiers.org/ncbigene:18641",
    "https://identifiers.org/ncbigene:16476",
    "https://identifiers.org/ncbigene:21803",
    "https://identifiers.org/ncbigene:56717",
    "https://identifiers.org/ncbigene:2162",
    "https://identifiers.org/ncbigene:20846",
    "https://identifiers.org/ncbigene:17127",
    "https://identifiers.org/ncbigene:18033"
  ],
  "mesh_gene_pubtator_kw": [
    "transforming growth factor-beta",
    "PFKL",
    "phosphofructokinase-1 liver type",
    "AP-1",
    "TGF-beta",
    "mTOR",
    "F13A1",
    "STAT1",
    "SMAD3",
    "NF-kappaB",
    "TGFBRI"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS6886",
  "study_findings": "TGF-\u03b2 regulates glycolysis and cytokine production, affecting sepsis survival.",
  "study_observation": "Macrophage metabolism regulation and its effects on sepsis.",
  "study_summary": "TGF-\u03b2 affects macrophage metabolism and sepsis survival.",
  "study_title_original": "TGF-\u03b2 uncouples glycolysis and inflammation in macrophages and controls the survival during sepsis"
}