Exercise-generated β-aminoisobutyric acid (BAIBA) reduces cardiomyocytes metabolic stress and apoptosis caused by mitochondrial dysfunction through the miR-208b/AMPK pathway

Study details

Source ID

https://identifiers.org/metabolights:MTBLS3927

Title

Exercise-generated β-aminoisobutyric acid (BAIBA) reduces cardiomyocytes metabolic stress and apoptosis caused by mitochondrial dysfunction through the miR-208b/AMPK pathway

Summary

BAIBA reduces cardiomyocyte stress via miR-208b/AMPK.

Observation

Cardiomyocyte apoptosis, energy metabolism, mitochondrial dysfunction, BAIBA effects.

Findings

BAIBA reduces stress and apoptosis through miR-208b/AMPK pathway.

Disease terms

heart failure, HF, Mitochondrial Dysfunction, cardiac remodeling, myocardial infarction, adverse, mitochondrial dysfunction

Gene terms

AMPK, miR-208b

Chemical terms

BAIBA, lipid, H2O2, ROS, H2 O 2, reactive oxygen species, fatty acid, beta-Aminoisobutyric Acid, ATP

Organisms

rat, Rats, rats

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS3927.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0005739",
    "https://identifiers.org/GO:0005737",
    "https://identifiers.org/GO:0016310",
    "https://identifiers.org/GO:0006915",
    "https://identifiers.org/GO:0140354"
  ],
  "go_kw": [
    "mitochondrion",
    "cytoplasm",
    "phosphorylation",
    "apoptosis",
    "lipid uptake"
  ],
  "integmet_study": "MTBLS3927",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:C033435",
    "https://identifiers.org/mesh:D008055",
    "https://identifiers.org/mesh:D006861",
    "https://identifiers.org/mesh:D017382",
    "https://identifiers.org/mesh:D005227",
    "https://identifiers.org/mesh:D000255"
  ],
  "mesh_chemical_pubtator_kw": [
    "BAIBA",
    "lipid",
    "H2O2",
    "ROS",
    "H2 O 2",
    "reactive oxygen species",
    "fatty acid",
    "beta-Aminoisobutyric Acid",
    "ATP"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D006333",
    "https://identifiers.org/mesh:D028361",
    "https://identifiers.org/mesh:D020257",
    "https://identifiers.org/mesh:D009203",
    "https://identifiers.org/mesh:D064420"
  ],
  "mesh_disease_pubtator_kw": [
    "heart failure",
    "HF",
    "Mitochondrial Dysfunction",
    "cardiac remodeling",
    "myocardial infarction",
    "adverse",
    "mitochondrial dysfunction"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:78975",
    "https://identifiers.org/ncbigene:100526635"
  ],
  "mesh_gene_pubtator_kw": [
    "AMPK",
    "miR-208b"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:10116"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "rat",
    "Rats",
    "rats"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS3927",
  "study_findings": "BAIBA reduces stress and apoptosis through miR-208b/AMPK pathway.",
  "study_observation": "Cardiomyocyte apoptosis, energy metabolism, mitochondrial dysfunction, BAIBA effects.",
  "study_summary": "BAIBA reduces cardiomyocyte stress via miR-208b/AMPK.",
  "study_title_original": "Exercise-generated \u03b2-aminoisobutyric acid (BAIBA) reduces cardiomyocytes metabolic stress and apoptosis caused by mitochondrial dysfunction through the miR-208b/AMPK pathway"
}