4-Octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING

Study details

Source ID

https://identifiers.org/metabolights:MTBLS5877

Title

4-Octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING

Summary

4-OI inhibits inflammation via STING alkylation.

Observation

4-Octyl itaconate's effect on STING signaling and inflammation.

Findings

4-OI alkylates STING, inhibiting phosphorylation and inflammatory factor production.

Disease terms

sepsis, inflammatory, inflammation

Gene terms

immune response gene 1, stimulator of interferon genes, STING, IRG1

Chemical terms

itaconate, 4-OI, 4-octyl itaconate

Organisms

—

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS5877.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0006954",
    "https://identifiers.org/GO:0008152",
    "https://identifiers.org/GO:0016310",
    "https://identifiers.org/GO:0005737",
    "https://identifiers.org/GO:0005783",
    "https://identifiers.org/GO:0006099",
    "https://identifiers.org/GO:0023052"
  ],
  "go_kw": [
    "inflammation",
    "metabolism",
    "phosphorylation",
    "cytoplasm",
    "endoplasmic reticulum",
    "Krebs cycle",
    "signaling"
  ],
  "integmet_study": "MTBLS5877",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:C005229",
    "https://identifiers.org/mesh:C000708109"
  ],
  "mesh_chemical_pubtator_kw": [
    "itaconate",
    "4-OI",
    "4-octyl itaconate"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D018805",
    "https://identifiers.org/mesh:D007249"
  ],
  "mesh_disease_pubtator_kw": [
    "sepsis",
    "inflammatory",
    "inflammation"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:730249",
    "https://identifiers.org/ncbigene:340061"
  ],
  "mesh_gene_pubtator_kw": [
    "immune response gene 1",
    "stimulator of interferon genes",
    "STING",
    "IRG1"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS5877",
  "study_findings": "4-OI alkylates STING, inhibiting phosphorylation and inflammatory factor production.",
  "study_observation": "4-Octyl itaconate\u0027s effect on STING signaling and inflammation.",
  "study_summary": "4-OI inhibits inflammation via STING alkylation.",
  "study_title_original": "4-Octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING"
}