GABA regulates IL-1β production in macrophages

Study details

Source ID

https://identifiers.org/metabolights:MTBLS6337

Title

GABA regulates IL-1β production in macrophages

Summary

GABA regulates macrophage maturation and inflammation.

Observation

GABA's effect on macrophage maturation and IL-1β production.

Findings

GABA inhibits IL-1β production and alleviates sepsis and obesity in mice.

Disease terms

obesity, inflammation, inflammatory diseases, sepsis, inflammatory

Gene terms

IL-1beta, ASC, Caspase-1, NLRP3, interleukin (IL)-1beta, Dusp2, LSD1, Bcl2l11

Chemical terms

LPS, lipopolysaccharides, GABA, gamma-amino butyric acid, succinate

Organisms

mice

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS6337.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0006954",
    "https://identifiers.org/GO:0005737",
    "https://identifiers.org/GO:0005634",
    "https://identifiers.org/GO:0018335",
    "https://identifiers.org/GO:0006119"
  ],
  "go_kw": [
    "inflammation",
    "cytoplasm",
    "nucleus",
    "protein succinylation",
    "oxidative phosphorylation"
  ],
  "integmet_study": "MTBLS6337",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D008070",
    "https://identifiers.org/mesh:D005680",
    "https://identifiers.org/mesh:D019802"
  ],
  "mesh_chemical_pubtator_kw": [
    "LPS",
    "lipopolysaccharides",
    "GABA",
    "gamma-amino butyric acid",
    "succinate"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D009765",
    "https://identifiers.org/mesh:D007249",
    "https://identifiers.org/mesh:D018805"
  ],
  "mesh_disease_pubtator_kw": [
    "obesity",
    "inflammation",
    "inflammatory diseases",
    "sepsis",
    "inflammatory"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:16176",
    "https://identifiers.org/ncbigene:20905",
    "https://identifiers.org/ncbigene:12362",
    "https://identifiers.org/ncbigene:216799",
    "https://identifiers.org/ncbigene:13537",
    "https://identifiers.org/ncbigene:99982",
    "https://identifiers.org/ncbigene:12125"
  ],
  "mesh_gene_pubtator_kw": [
    "IL-1beta",
    "ASC",
    "Caspase-1",
    "NLRP3",
    "interleukin (IL)-1beta",
    "Dusp2",
    "LSD1",
    "Bcl2l11"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:10090"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "mice"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS6337",
  "study_findings": "GABA inhibits IL-1\u03b2 production and alleviates sepsis and obesity in mice.",
  "study_observation": "GABA\u0027s effect on macrophage maturation and IL-1\u03b2 production.",
  "study_summary": "GABA regulates macrophage maturation and inflammation.",
  "study_title_original": "GABA regulates IL-1\u03b2 production in macrophages"
}