DNA-PKcs drives CKD progression by activating TAF7/RAPTOR/mTORC1 signaling-mediated metabolic reprogramming

Study details

Source ID

https://identifiers.org/metabolights:MTBLS5971

Title

DNA-PKcs drives CKD progression by activating TAF7/RAPTOR/mTORC1 signaling-mediated metabolic reprogramming

Summary

DNA-PKcs affects CKD via TAF7/mTORC1 signaling.

Observation

Expression of DNA-PKcs in CKD patients and mice.

Findings

DNA-PKcs inhibition corrects metabolic reprogramming via TAF7/mTORC1 signaling in CKD.

Disease terms

ischemia-reperfusion injury, chronic kidney disease, Kidney injury, ureteral obstruction

Gene terms

DNA-dependent protein kinase catalytic subunit, DNA-PKcs, transforming growth factor-beta 1, RAPTOR, TAF7

Chemical terms

NU7441

Organisms

patients, mice

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS5971.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0016301",
    "https://identifiers.org/GO:0005737",
    "https://identifiers.org/GO:0005634",
    "https://identifiers.org/GO:0072537",
    "https://identifiers.org/GO:0005615"
  ],
  "go_kw": [
    "kinase activity",
    "cytoplasm",
    "nucleus",
    "fibroblast activation",
    "extracellular space"
  ],
  "integmet_study": "MTBLS5971",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:C499693"
  ],
  "mesh_chemical_pubtator_kw": [
    "NU7441"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D015427",
    "https://identifiers.org/mesh:D051436",
    "https://identifiers.org/mesh:D007674",
    "https://identifiers.org/mesh:D014517"
  ],
  "mesh_disease_pubtator_kw": [
    "ischemia-reperfusion injury",
    "chronic kidney disease",
    "Kidney injury",
    "ureteral obstruction"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:19090",
    "https://identifiers.org/ncbigene:21803",
    "https://identifiers.org/ncbigene:74370",
    "https://identifiers.org/ncbigene:24074"
  ],
  "mesh_gene_pubtator_kw": [
    "DNA-dependent protein kinase catalytic subunit",
    "DNA-PKcs",
    "transforming growth factor-beta 1",
    "RAPTOR",
    "TAF7"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:9606",
    "https://identifiers.org/taxonomy:10090"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "patients",
    "mice"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS5971",
  "study_findings": "DNA-PKcs inhibition corrects metabolic reprogramming via TAF7/mTORC1 signaling in CKD.",
  "study_observation": "Expression of DNA-PKcs in CKD patients and mice.",
  "study_summary": "DNA-PKcs affects CKD via TAF7/mTORC1 signaling.",
  "study_title_original": "DNA-PKcs drives CKD progression by activating TAF7/RAPTOR/mTORC1 signaling-mediated metabolic reprogramming"
}