Diff Profiles › MTBLS5971_0001_00000001

DNA-PK_KO_UUO_vs_DNA-PK_KO_Control

DNA-PK KO UUO vs DNA-PK KO Control

p-value ≤ 0.05 29 significant 2025-09-26 00:00:00 Study: MTBLS5971
75 Total Features
29 Significant
0.05 p-value Threshold

Profile details

Identifier
MTBLS5971_0001_00000001
Linked study
MTBLS5971 — DNA-PKcs drives CKD progression by activating TAF7/RAPTOR/mTORC1 signaling-mediated metabolic reprogramming
Comparison
DNA-PK KO UUO vs DNA-PK KO Control
Group A
DNA-PK knockout mice with unilateral ureteral obstruction. Key group for studying the effects of DNA-PK knockout on CKD progression
Group B
DNA-PK knockout mice without induced CKD. Provides baseline data for comparison with UUO-induced DNA-PK KO samples
Total features tested
75
Significant features
29
p-value threshold
0.05
Ratio threshold (upper)
1.5
Ratio threshold (lower)
1/1.5
Date created
2025-09-26 00:00:00

Top hits

Metabolite ID (InChI Key) Name Direction Ratio p-value
WBYWAXJHAXSJNI-VOTSOKGWSA-N trans-Cinnamic acid up 9.837e+04 0.024
YSMODUONRAFBET-UHFFFAOYSA-N hydroxylysine up 9.583 0.027
UGQMRVRMYYASKQ-KQYNXXCUSA-N hypoxanthine <small>D</small>-riboside up 1.832 3.18e-06
GXYLOXCSJFJFKA-IOSLPCCCSA-N 9-(5-<em>S</em>-methyl-5-thio-β-<small>D</small>-ribofuranosyl)-9<em>H</em>-purin-6-ol up 2.338 0.000163
NYHBQMYGNKIUIF-UUOKFMHZSA-N G up 2.33 0.000186
UYTPUPDQBNUYGX-UHFFFAOYSA-N GUANINE up 2.294 0.000162
OIRDTQYFTABQOQ-KQYNXXCUSA-N Adenosin up 2.061 4.7e-05
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-2-Amino-3-hydroxybutyric acid up 5.656 0.0174
DRTQHJPVMGBUCF-XVFCMESISA-N u up 2.6 0.000789
ODHCTXKNWHHXJC-VKHMYHEASA-N (−)-2-pyrrolidone-5-carboxylic acid up 3.271 0.00628