{"@type":"Dataset","go_id":["https://identifiers.org/GO:0016301","https://identifiers.org/GO:0005737","https://identifiers.org/GO:0005634","https://identifiers.org/GO:0072537","https://identifiers.org/GO:0005615"],"go_kw":["kinase activity","cytoplasm","nucleus","fibroblast activation","extracellular space"],"integmet_study":"MTBLS5971","mesh_chemical_id":["https://identifiers.org/mesh:C499693"],"mesh_chemical_pubtator_kw":["NU7441"],"mesh_disease_id":["https://identifiers.org/mesh:D015427","https://identifiers.org/mesh:D051436","https://identifiers.org/mesh:D007674","https://identifiers.org/mesh:D014517"],"mesh_disease_pubtator_kw":["ischemia-reperfusion injury","chronic kidney disease","Kidney injury","ureteral obstruction"],"mesh_gene_id":["https://identifiers.org/ncbigene:19090","https://identifiers.org/ncbigene:21803","https://identifiers.org/ncbigene:74370","https://identifiers.org/ncbigene:24074"],"mesh_gene_pubtator_kw":["DNA-dependent protein kinase catalytic subunit","DNA-PKcs","transforming growth factor-beta 1","RAPTOR","TAF7"],"ncbi_taxonomy_id":["https://identifiers.org/taxonomy:9606","https://identifiers.org/taxonomy:10090"],"ncbi_taxonomy_pubtator_kw":["patients","mice"],"source_id":"https://identifiers.org/metabolights:MTBLS5971","study_findings":"DNA-PKcs inhibition corrects metabolic reprogramming via TAF7/mTORC1 signaling in CKD.","study_observation":"Expression of DNA-PKcs in CKD patients and mice.","study_summary":"DNA-PKcs affects CKD via TAF7/mTORC1 signaling.","study_title_original":"DNA-PKcs drives CKD progression by activating TAF7/RAPTOR/mTORC1 signaling-mediated metabolic reprogramming"}