Extracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness

Study details

Source ID

https://identifiers.org/metabolights:MTBLS6661

Title

Extracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness

Summary

Extracellular-acidosis affects T cell metabolism and stemness.

Observation

Impact of extracellular-acidosis on T cell metabolic fitness and differentiation.

Findings

Acidosis impairs methionine metabolism, preserving T cell stemness and enhancing anti-tumor efficacy.

Disease terms

acidosis, tumor

Gene terms

SLC7A5

Chemical terms

methionine

Organisms

mice

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS6661.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0030154",
    "https://identifiers.org/GO:0006555",
    "https://identifiers.org/GO:0008152"
  ],
  "go_kw": [
    "cell differentiation",
    "methionine metabolism",
    "metabolism"
  ],
  "integmet_study": "MTBLS6661",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D008715"
  ],
  "mesh_chemical_pubtator_kw": [
    "methionine"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D000138",
    "https://identifiers.org/mesh:D009369"
  ],
  "mesh_disease_pubtator_kw": [
    "acidosis",
    "tumor"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:20539"
  ],
  "mesh_gene_pubtator_kw": [
    "SLC7A5"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:10090"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "mice"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS6661",
  "study_findings": "Acidosis impairs methionine metabolism, preserving T cell stemness and enhancing anti-tumor efficacy.",
  "study_observation": "Impact of extracellular-acidosis on T cell metabolic fitness and differentiation.",
  "study_summary": "Extracellular-acidosis affects T cell metabolism and stemness.",
  "study_title_original": "Extracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness"
}