Diff Profiles › MTBLS7713_0001_00000003

SAR-R_vs_SAR-S

SAR-R Group vs SAR-S Group

p-value ≤ 0.05 55 significant 2025-09-26 00:00:00 Study: MTBLS7713
184 Total Features
55 Significant
0.05 p-value Threshold

Profile details

Identifier
MTBLS7713_0001_00000003
Linked study
MTBLS7713 — L-leucine increases the sensitivity of drug-resistant Salmonella to sarafloxacin by stimulating central carbon metabolism and increasing intracellular reactive oxygen species level (LC-MS negative mode)
Comparison
SAR-R Group vs SAR-S Group
Group A
Sarafloxacin-resistant Salmonella Typhimurium samples. Key group for studying the effects of drug resistance on metabolism.
Group B
Sarafloxacin-susceptible Salmonella Typhimurium samples. Serves as a comparison group to understand the metabolic differences due to drug resistance.
Total features tested
184
Significant features
55
p-value threshold
0.05
Ratio threshold (upper)
1.5
Ratio threshold (lower)
1/1.5
Date created
2025-09-26 00:00:00

Top hits

Metabolite ID (InChI Key) Name Direction Ratio p-value
POJWUDADGALRAB-UHFFFAOYSA-N (2,5-Dioxo-4-imidazolidinyl)urea up 3.485 1.51e-08
WQZGKKKJIJFFOK-PQMKYFCFSA-N ALPHA-D-MANNOSE down 0.3732 7.86e-06
AFENDNXGAFYKQO-UHFFFAOYSA-N 2-Hydroxybutanoic acid down 0.3031 7.2e-05
OWQDWQKWSLFFFR-WDSKDSINSA-N (5-L-Glutamyl)-L-glutamate up 2.363 7.77e-06
BRGMHAYQAZFZDJ-RTRLPJTCSA-N 2-acetamido-2-deoxy-6-<em>O</em>-phosphono-<small>D</small>-glucopyranose down 0.4229 2.25e-05
RWSXRVCMGQZWBV-WDSKDSINSA-N 5-L-Glutamyl-L-cysteinylglycine down 0.2219 0.00235
OTCCIMWXFLJLIA-BYPYZUCNSA-N <em>N</em>-acetylaspartic acid down 0.4368 2.57e-05
VZCYOOQTPOCHFL-UPHRSURJSA-N Maleic acid down 0.4758 1.86e-05
DCWXELXMIBXGTH-UHFFFAOYSA-N phosphotyrosine down 0.3013 0.00219
DKEXFJVMVGETOO-LURJTMIESA-N Glycyl-L-leucine up 2.354 0.000288