L-leucine increases the sensitivity of drug-resistant Salmonella to sarafloxacin by stimulating central carbon metabolism and increasing intracellular reactive oxygen species level (LC-MS negative mode)

Study details

Source ID

https://identifiers.org/metabolights:MTBLS7713

Title

L-leucine increases the sensitivity of drug-resistant Salmonella to sarafloxacin by stimulating central carbon metabolism and increasing intracellular reactive oxygen species level (LC-MS negative mode)

Summary

L-leucine enhances sarafloxacin effect on resistant Salmonella.

Observation

Metabolic differences between sarafloxacin-susceptible and resistant Salmonella Typhimurium.

Findings

L-leucine increases sarafloxacin efficacy by stimulating metabolism and reactive oxygen species in resistant Salmonella.

Disease terms

SAR-R, SAR-S

Gene terms

—

Chemical terms

L-leucine, NADH, fluoroquinolone, reactive oxygen species, TCA, sarafloxacin, carbon, ATP

Organisms

Salmonella Typhimurium, Salmonella

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS7713.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0006099",
    "https://identifiers.org/GO:0008152",
    "https://identifiers.org/GO:0006118"
  ],
  "go_kw": [
    "TCA cycle",
    "metabolism",
    "electron transfer"
  ],
  "integmet_study": "MTBLS7713",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D007930",
    "https://identifiers.org/mesh:D009243",
    "https://identifiers.org/mesh:D024841",
    "https://identifiers.org/mesh:D017382",
    "https://identifiers.org/mesh:D014238",
    "https://identifiers.org/mesh:C047224",
    "https://identifiers.org/mesh:D002244",
    "https://identifiers.org/mesh:D000255"
  ],
  "mesh_chemical_pubtator_kw": [
    "L-leucine",
    "NADH",
    "fluoroquinolone",
    "reactive oxygen species",
    "TCA",
    "sarafloxacin",
    "carbon",
    "ATP"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D012480",
    "https://identifiers.org/mesh:C562694"
  ],
  "mesh_disease_pubtator_kw": [
    "SAR-R",
    "SAR-S"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:90371"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "Salmonella Typhimurium",
    "Salmonella"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS7713",
  "study_findings": "L-leucine increases sarafloxacin efficacy by stimulating metabolism and reactive oxygen species in resistant Salmonella.",
  "study_observation": "Metabolic differences between sarafloxacin-susceptible and resistant Salmonella Typhimurium.",
  "study_summary": "L-leucine enhances sarafloxacin effect on resistant Salmonella.",
  "study_title_original": "L-leucine increases the sensitivity of drug-resistant Salmonella to sarafloxacin by stimulating central carbon metabolism and increasing intracellular reactive oxygen species level (LC-MS negative mode)"
}