Anti-anemia drug FG4592 retards the AKI to CKD transition by improving vascular regeneration and anti-oxidative capability (day 21)

Study details

Source ID

https://identifiers.org/metabolights:MTBLS3003

Title

Anti-anemia drug FG4592 retards the AKI to CKD transition by improving vascular regeneration and anti-oxidative capability (day 21)

Summary

FG4592 prevents AKI-to-CKD transition.

Observation

Role of FG4592 in AKI-to-CKD transition induced by UIR.

Findings

FG4592 alleviates kidney fibrosis, enhances vascular regeneration, and improves redox balance.

Disease terms

hypoxia, -anemia, Damage to the renal vascular system, metabolic disorders, acute, kidney fibrosis, CKD, chronic kidney disease, Acute kidney injury, anemia, unilateral kidney ischemia-, ischemic damage, ischemia, AKI, inflammatory

Gene terms

VEGFA, VEGFR1, SOD2, HIF-1alpha, vascular endothelial growth factor A, superoxide dismutase 2

Chemical terms

Roxadustat, FG4592

Organisms

patients, mice

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS3003.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0005739",
    "https://identifiers.org/GO:0005634",
    "https://identifiers.org/GO:0006954",
    "https://identifiers.org/GO:0005886",
    "https://identifiers.org/GO:0016209",
    "https://identifiers.org/GO:0005615"
  ],
  "go_kw": [
    "mitochondrion",
    "nucleus",
    "inflammatory response",
    "cell membrane",
    "antioxidant activity",
    "extracellular space"
  ],
  "integmet_study": "MTBLS3003",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:C584543"
  ],
  "mesh_chemical_pubtator_kw": [
    "Roxadustat",
    "FG4592"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D000860",
    "https://identifiers.org/mesh:D000740",
    "https://identifiers.org/mesh:D020785",
    "https://identifiers.org/mesh:D008659",
    "https://identifiers.org/mesh:D000208",
    "https://identifiers.org/mesh:D007674",
    "https://identifiers.org/mesh:D051436",
    "https://identifiers.org/mesh:D058186",
    "https://identifiers.org/mesh:D007680",
    "https://identifiers.org/mesh:D017202",
    "https://identifiers.org/mesh:D007511",
    "https://identifiers.org/mesh:D007249"
  ],
  "mesh_disease_pubtator_kw": [
    "hypoxia",
    "-anemia",
    "Damage to the renal vascular system",
    "metabolic disorders",
    "acute",
    "kidney fibrosis",
    "CKD",
    "chronic kidney disease",
    "Acute kidney injury",
    "anemia",
    "unilateral kidney ischemia-",
    "ischemic damage",
    "ischemia",
    "AKI",
    "inflammatory"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:7422",
    "https://identifiers.org/ncbigene:22339",
    "https://identifiers.org/ncbigene:14254",
    "https://identifiers.org/ncbigene:6648",
    "https://identifiers.org/ncbigene:15251",
    "https://identifiers.org/ncbigene:3091",
    "https://identifiers.org/ncbigene:20656"
  ],
  "mesh_gene_pubtator_kw": [
    "VEGFA",
    "VEGFR1",
    "SOD2",
    "HIF-1alpha",
    "vascular endothelial growth factor A",
    "superoxide dismutase 2"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:9606",
    "https://identifiers.org/taxonomy:10090"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "patients",
    "mice"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS3003",
  "study_findings": "FG4592 alleviates kidney fibrosis, enhances vascular regeneration, and improves redox balance.",
  "study_observation": "Role of FG4592 in AKI-to-CKD transition induced by UIR.",
  "study_summary": "FG4592 prevents AKI-to-CKD transition.",
  "study_title_original": "Anti-anemia drug FG4592 retards the AKI\u00a0to CKD transition by improving vascular regeneration and anti-oxidative capability (day 21)"
}