Integrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRα deficiency.

Study details

Source ID

https://identifiers.org/metabolights:MTBLS795

Title

Integrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRα deficiency.

Summary

Cardiac remodeling due to ErbB2 and ERRα deficiency.

Observation

Adverse cardiac remodeling and metabolic inflexibility in mice.

Findings

ErbB2 and ERRα deficiency affects cardiomyocyte architecture, inflammation, and metabolism.

Disease terms

breast and other cancers, breast cancer, cardiac remodeling, inflammatory, cardiotoxicity

Gene terms

ERRalpha, ErbB2, HER2

Chemical terms

glucose, doxorubicin

Organisms

mice, patients

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS795.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0008152",
    "https://identifiers.org/GO:0016310",
    "https://identifiers.org/GO:0005634",
    "https://identifiers.org/GO:0006954",
    "https://identifiers.org/GO:0006351",
    "https://identifiers.org/GO:0005886"
  ],
  "go_kw": [
    "metabolism",
    "phosphorylation",
    "nucleus",
    "inflammatory response",
    "transcription",
    "cell membrane"
  ],
  "integmet_study": "MTBLS795",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D005947",
    "https://identifiers.org/mesh:D004317"
  ],
  "mesh_chemical_pubtator_kw": [
    "glucose",
    "doxorubicin"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D001943",
    "https://identifiers.org/mesh:D020257",
    "https://identifiers.org/mesh:D007249",
    "https://identifiers.org/mesh:D066126"
  ],
  "mesh_disease_pubtator_kw": [
    "breast and other cancers",
    "breast cancer",
    "cardiac remodeling",
    "inflammatory",
    "cardiotoxicity"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:26379",
    "https://identifiers.org/ncbigene:2064",
    "https://identifiers.org/ncbigene:2101",
    "https://identifiers.org/ncbigene:13866"
  ],
  "mesh_gene_pubtator_kw": [
    "ERRalpha",
    "ErbB2",
    "HER2"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:10090",
    "https://identifiers.org/taxonomy:9606"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "mice",
    "patients"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS795",
  "study_findings": "ErbB2 and ERR\u03b1 deficiency affects cardiomyocyte architecture, inflammation, and metabolism.",
  "study_observation": "Adverse cardiac remodeling and metabolic inflexibility in mice.",
  "study_summary": "Cardiac remodeling due to ErbB2 and ERR\u03b1 deficiency.",
  "study_title_original": "Integrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERR\u03b1 deficiency."
}