Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors

Study details

Source ID

https://identifiers.org/metabolights:MTBLS4722

Title

Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors

Summary

Pancreatic tumors sensitive to IDH1 inhibitors.

Observation

Nutrient-deprived tumor microenvironment in pancreatic cancer cells.

Findings

Allosteric IDH1 inhibitors are effective under low magnesium, inhibiting tumor growth.

Disease terms

pancreatic tumors, pancreatic cancer, tumor, cancer

Gene terms

IDH1

Chemical terms

AG-120, alphaKG, alpha-ketoglutarate, free radicals, NADPH, magnesium, ivosidenib, isocitrate

Organisms

—

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS4722.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0005829"
  ],
  "go_kw": [
    "cytosol"
  ],
  "integmet_study": "MTBLS4722",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:C000627630",
    "https://identifiers.org/mesh:D007656",
    "https://identifiers.org/mesh:D005609",
    "https://identifiers.org/mesh:D009249",
    "https://identifiers.org/mesh:D008274",
    "https://identifiers.org/mesh:C034219"
  ],
  "mesh_chemical_pubtator_kw": [
    "AG-120",
    "alphaKG",
    "alpha-ketoglutarate",
    "free radicals",
    "NADPH",
    "magnesium",
    "ivosidenib",
    "isocitrate"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D010190",
    "https://identifiers.org/mesh:D009369"
  ],
  "mesh_disease_pubtator_kw": [
    "pancreatic tumors",
    "pancreatic cancer",
    "tumor",
    "cancer"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:3417"
  ],
  "mesh_gene_pubtator_kw": [
    "IDH1"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS4722",
  "study_findings": "Allosteric IDH1 inhibitors are effective under low magnesium, inhibiting tumor growth.",
  "study_observation": "Nutrient-deprived tumor microenvironment in pancreatic cancer cells.",
  "study_summary": "Pancreatic tumors sensitive to IDH1 inhibitors.",
  "study_title_original": "Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors"
}