Wild_Type_vs_Gene_Knockout

Profile details

Identifier: MTBLS4722_0001_00000001
Linked study: MTBLS4722 — Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors
Comparison: Wild_Type vs Gene_Knockout
Group A: Wild-type IDH1 samples under nutrient-deprived conditions.. Serves as the control group to evaluate the effects of IDH1 gene knockout.
Group B: IDH1 gene knockout samples under nutrient-deprived conditions.. Allows for the assessment of the impact of IDH1 gene knockout on cell viability under nutrient-deprived conditions.
Total features tested: 228
Significant features: 82
p-value threshold: 0.05
Ratio threshold (upper): 1.5
Ratio threshold (lower): 1/1.5
Date created: 2025-09-26 00:00:00

Metabolite ID (InChI Key)	Name	Direction	Ratio	p-value
HSCJRCZFDFQWRP-LPTOLDDLSA-N	[[(2S,3R,4S,5S)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(3S,4R,5R,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hydrogen phosphate	up	449.9	9.09e-10
LEVWYRKDKASIDU-IMJSIDKUSA-N	(2<i>R</i>,2'<i>R</i>)-3,3'-dithiobis(2-ammoniopropanoate)	up	225.1	4.96e-09
HSCJRCZFDFQWRP-ABVWGUQPSA-N	Uridinediphosphogalactose	up	149.2	1.06e-09
UBORTCNDUKBEOP-UUOKFMHZSA-N	9-β-<small>D</small>-ribofuranosyl-3,9-dihydro-1<em>H</em>-purine-2,6-dione	up	305.9	2.19e-07
LCQLHJZYVOQKHU-VKHMYHEASA-N	Carbamylglutamic acid	up	109	7.12e-08
PGAVKCOVUIYSFO-XVFCMESISA-N	H<small><sub>4</sub></small>utp	up	44.8	4.98e-09
LFTYTUAZOPRMMI-CFRASDGPSA-N	(2R,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name)	up	66.76	1.2e-07
DCXYFEDJOCDNAF-REOHCLBHSA-N	(2<i>S</i>)-2-ammonio-3-carbamoylpropanoate	up	42.44	4.81e-08
AYFVYJQAPQTCCC-GBXIJSLDSA-N	L-2-Amino-3-hydroxybutyric acid	up	26.03	1.29e-08
PCDQPRRSZKQHHS-XVFCMESISA-N	5'-CTP	up	29.37	4.69e-08