Fatty acid oxidation protects cancer cells from apoptosis through increasing mitochondrial membrane lipids

Study details

Source ID

https://identifiers.org/metabolights:MTBLS4709

Title

Fatty acid oxidation protects cancer cells from apoptosis through increasing mitochondrial membrane lipids

Summary

FAO protects cancer cells from apoptosis.

Observation

Role of fatty acid β-Oxidation in chemoresistance.

Findings

Elevated FAO activates STAT3, increasing mitochondrial phospholipids, protecting against apoptosis.

Disease terms

cancer

Gene terms

—

Chemical terms

Fatty acid, lipids

Organisms

—

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS4709.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0005739",
    "https://identifiers.org/GO:0005737",
    "https://identifiers.org/GO:0008654",
    "https://identifiers.org/GO:0006915"
  ],
  "go_kw": [
    "mitochondrion",
    "cytoplasm",
    "phospholipid synthesis",
    "apoptosis"
  ],
  "integmet_study": "MTBLS4709",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D005227",
    "https://identifiers.org/mesh:D008055"
  ],
  "mesh_chemical_pubtator_kw": [
    "Fatty acid",
    "lipids"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D009369"
  ],
  "mesh_disease_pubtator_kw": [
    "cancer"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS4709",
  "study_findings": "Elevated FAO activates STAT3, increasing mitochondrial phospholipids, protecting against apoptosis.",
  "study_observation": "Role of fatty acid \u03b2-Oxidation in chemoresistance.",
  "study_summary": "FAO protects cancer cells from apoptosis.",
  "study_title_original": "Fatty acid oxidation protects cancer cells from apoptosis through increasing mitochondrial membrane lipids"
}