Diallyl disulfide (DADS) ameliorates intestinal Candida albicans infection by modulating the gut microbiota and metabolites and providing intestinal protection in mice

Study details

Source ID

https://identifiers.org/metabolights:MTBLS3750

Title

Diallyl disulfide (DADS) ameliorates intestinal Candida albicans infection by modulating the gut microbiota and metabolites and providing intestinal protection in mice

Summary

DADS ameliorates intestinal C. albicans infection in mice.

Observation

Gut microbiota, metabolites, body weight, survival, colon length, histological score, inflammatory cytokine levels.

Findings

DADS alters gut microbiota, increases SCFA-producing bacteria, and improves metabolic pathways in infected mice.

Disease terms

inflammatory, inflammation, C. albicans infection

Gene terms

—

Chemical terms

Diallyl Disulfide, Diallyl disulfide, indoles, tryptophan, DADS, arachidonic acid, allicin, SCFA, dextran sulfate, bile acids

Organisms

mice, Ruminiclostridium, Oscillibacter, Streptococcus, C. albicans, Shigella, Mice, Escherichia

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS3750.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0006568",
    "https://identifiers.org/GO:0019369"
  ],
  "go_kw": [
    "tryptophan metabolism",
    "arachidonic acid metabolism"
  ],
  "integmet_study": "MTBLS3750",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:C028009",
    "https://identifiers.org/mesh:D007211",
    "https://identifiers.org/mesh:D014364",
    "https://identifiers.org/mesh:D016718",
    "https://identifiers.org/mesh:C006452",
    "https://identifiers.org/mesh:D005232",
    "https://identifiers.org/mesh:D016264",
    "https://identifiers.org/mesh:D001647"
  ],
  "mesh_chemical_pubtator_kw": [
    "Diallyl Disulfide",
    "Diallyl disulfide",
    "indoles",
    "tryptophan",
    "DADS",
    "arachidonic acid",
    "allicin",
    "SCFA",
    "dextran sulfate",
    "bile acids"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D007249",
    "https://identifiers.org/mesh:D007239"
  ],
  "mesh_disease_pubtator_kw": [
    "inflammatory",
    "inflammation",
    "C. albicans infection"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:10090",
    "https://identifiers.org/taxonomy:1508657",
    "https://identifiers.org/taxonomy:459786",
    "https://identifiers.org/taxonomy:1301",
    "https://identifiers.org/taxonomy:5476",
    "https://identifiers.org/taxonomy:620",
    "https://identifiers.org/taxonomy:562"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "mice",
    "Ruminiclostridium",
    "Oscillibacter",
    "Streptococcus",
    "C. albicans",
    "Shigella",
    "Mice",
    "Escherichia"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS3750",
  "study_findings": "DADS alters gut microbiota, increases SCFA-producing bacteria, and improves metabolic pathways in infected mice.",
  "study_observation": "Gut microbiota, metabolites, body weight, survival, colon length, histological score, inflammatory cytokine levels.",
  "study_summary": "DADS ameliorates intestinal C. albicans infection in mice.",
  "study_title_original": "Diallyl disulfide (DADS) ameliorates intestinal Candida albicans infection by modulating the gut microbiota and metabolites and providing intestinal protection in mice"
}