Disturbed Microbiota-Metabolites-Immune Interaction Network is Associated with Olfactory Dysfunction in Patients with Chronic Rhinosinusitis

Study details

Source ID

https://identifiers.org/metabolights:MTBLS7584

Title

Disturbed Microbiota-Metabolites-Immune Interaction Network is Associated with Olfactory Dysfunction in Patients with Chronic Rhinosinusitis

Summary

Nasal microbiota-metabolite-immune interactions in CRS with OD.

Observation

Nasal microbiota, metabolites, and immune interactions in CRS patients.

Findings

Decreased microbiome diversity, enriched purine metabolism, elevated inflammatory mediators in OD group.

Disease terms

CRS, inflammation, OD, NOD, sinonasal inflammation, chronic rhinosinusitis, Olfactory dysfunction, olfactory dysfunction, inflammatory

Gene terms

MIP-1alpha, IL-5, TNF, MCP-1, IL-8

Chemical terms

purine

Organisms

patients, Aeromonas dhakensis, Acinetobacter johnsonii, Salmonella enterica, Mycoplasma arginini

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS7584.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0042278",
    "https://identifiers.org/GO:0006954",
    "https://identifiers.org/GO:0008152",
    "https://identifiers.org/GO:0006955"
  ],
  "go_kw": [
    "purine metabolism",
    "inflammation",
    "metabolism",
    "immune response"
  ],
  "integmet_study": "MTBLS7584",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:C030985"
  ],
  "mesh_chemical_pubtator_kw": [
    "purine"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D000092562",
    "https://identifiers.org/mesh:D007249",
    "https://identifiers.org/mesh:D000857",
    "https://identifiers.org/mesh:D020191"
  ],
  "mesh_disease_pubtator_kw": [
    "CRS",
    "inflammation",
    "OD",
    "NOD",
    "sinonasal inflammation",
    "chronic rhinosinusitis",
    "Olfactory dysfunction",
    "olfactory dysfunction",
    "inflammatory"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:6348",
    "https://identifiers.org/ncbigene:3567",
    "https://identifiers.org/ncbigene:7124",
    "https://identifiers.org/ncbigene:6347",
    "https://identifiers.org/ncbigene:3576"
  ],
  "mesh_gene_pubtator_kw": [
    "MIP-1alpha",
    "IL-5",
    "TNF",
    "MCP-1",
    "IL-8"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:9606",
    "https://identifiers.org/taxonomy:196024",
    "https://identifiers.org/taxonomy:40214",
    "https://identifiers.org/taxonomy:28901",
    "https://identifiers.org/taxonomy:2094"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "patients",
    "Aeromonas dhakensis",
    "Acinetobacter johnsonii",
    "Salmonella enterica",
    "Mycoplasma arginini"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS7584",
  "study_findings": "Decreased microbiome diversity, enriched purine metabolism, elevated inflammatory mediators in OD group.",
  "study_observation": "Nasal microbiota, metabolites, and immune interactions in CRS patients.",
  "study_summary": "Nasal microbiota-metabolite-immune interactions in CRS with OD.",
  "study_title_original": "Disturbed Microbiota-Metabolites-Immune Interaction Network is Associated with Olfactory Dysfunction in Patients with Chronic Rhinosinusitis"
}