Distinct succinate modifying products are clinically diagnostic and prognostic biomarkers for fumarate hydratase deficient renal cell carcinoma

Study details

Source ID

https://identifiers.org/metabolights:MTBLS3628

Title

Distinct succinate modifying products are clinically diagnostic and prognostic biomarkers for fumarate hydratase deficient renal cell carcinoma

Summary

Biomarkers for FH-deficient renal cell carcinoma identified.

Observation

Plasma metabolomics in FH-deficient RCC patients.

Findings

Succinyl-adenosine and succinic-cysteine are biomarkers with >90% predictive value.

Disease terms

FH-deficient tumors, tumors, renal cell carcinoma, tumor, RCC, fumarate hydratase-deficient renal cell carcinoma

Gene terms

FH, fumarate hydratase

Chemical terms

succinyl-adenosine, succinate

Organisms

patients

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS3628.

{
  "@type": "Dataset",
  "integmet_study": "MTBLS3628",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:C043565",
    "https://identifiers.org/mesh:D019802"
  ],
  "mesh_chemical_pubtator_kw": [
    "succinyl-adenosine",
    "succinate"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:C538191",
    "https://identifiers.org/mesh:D009369",
    "https://identifiers.org/mesh:D002292"
  ],
  "mesh_disease_pubtator_kw": [
    "FH-deficient tumors",
    "tumors",
    "renal cell carcinoma",
    "tumor",
    "RCC",
    "fumarate hydratase-deficient renal cell carcinoma"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:2271"
  ],
  "mesh_gene_pubtator_kw": [
    "FH",
    "fumarate hydratase"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:9606"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "patients"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS3628",
  "study_findings": "Succinyl-adenosine and succinic-cysteine are biomarkers with \u003e90% predictive value.",
  "study_observation": "Plasma metabolomics in FH-deficient RCC patients.",
  "study_summary": "Biomarkers for FH-deficient renal cell carcinoma identified.",
  "study_title_original": "Distinct succinate modifying products are clinically diagnostic and prognostic biomarkers for fumarate hydratase deficient renal cell carcinoma"
}