Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction

Study details

Source ID

https://identifiers.org/metabolights:MTBLS745

Title

Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction

Summary

Arginine starvation kills cancer cells via aspartate depletion.

Observation

Effects of arginine depletion on arginine-auxotrophic cancer cells.

Findings

Arginine starvation causes mitochondrial dysfunction and aspartate depletion, reducing tumor growth in ASS1-deficient breast cancer.

Disease terms

mitochondrial distress, breast cancer, cancer, tumor, mitochondrial dysfunction, arginine auxotrophy

Gene terms

argininosuccinate synthase 1, asparagine synthetase, ASNS, ASS1

Chemical terms

arginine, aspartate, malate, Arginine

Organisms

—

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS745.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0005739",
    "https://identifiers.org/GO:0005737",
    "https://identifiers.org/GO:0043490",
    "https://identifiers.org/GO:0008219",
    "https://identifiers.org/GO:0006526"
  ],
  "go_kw": [
    "mitochondrion",
    "cytoplasm",
    "malate-aspartate shuttle",
    "cell death",
    "arginine synthesis"
  ],
  "integmet_study": "MTBLS745",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D001120",
    "https://identifiers.org/mesh:D001224",
    "https://identifiers.org/mesh:C030298"
  ],
  "mesh_chemical_pubtator_kw": [
    "arginine",
    "aspartate",
    "malate",
    "Arginine"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D012128",
    "https://identifiers.org/mesh:D001943",
    "https://identifiers.org/mesh:D009369",
    "https://identifiers.org/mesh:D028361",
    "https://identifiers.org/mesh:C567192"
  ],
  "mesh_disease_pubtator_kw": [
    "mitochondrial distress",
    "breast cancer",
    "cancer",
    "tumor",
    "mitochondrial dysfunction",
    "arginine auxotrophy"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:445",
    "https://identifiers.org/ncbigene:440"
  ],
  "mesh_gene_pubtator_kw": [
    "argininosuccinate synthase 1",
    "asparagine synthetase",
    "ASNS",
    "ASS1"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS745",
  "study_findings": "Arginine starvation causes mitochondrial dysfunction and aspartate depletion, reducing tumor growth in ASS1-deficient breast cancer.",
  "study_observation": "Effects of arginine depletion on arginine-auxotrophic cancer cells.",
  "study_summary": "Arginine starvation kills cancer cells via aspartate depletion.",
  "study_title_original": "Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction"
}