Integrated Proteomics and Metabolomics Analysis Reveals Differential Lipid Metabolism in HUVEC under high and low shear stress

Study details

Source ID

https://identifiers.org/metabolights:MTBLS739

Title

Integrated Proteomics and Metabolomics Analysis Reveals Differential Lipid Metabolism in HUVEC under high and low shear stress

Summary

Lipid metabolism in HUVEC under shear stress.

Observation

Changes in endothelial cells under low and high shear stress.

Findings

Lipid metabolism downregulated under LSS; atorvastatin recapitulates HSS phenotype.

Disease terms

atherosclerosis, inflammatory, Atherosclerotic plaque

Gene terms

low-density lipoprotein receptor, LDLR

Chemical terms

cholesterol, atorvastatin, lipid

Organisms

human

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS739.

{
  "@type": "Dataset",
  "integmet_study": "MTBLS739",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D002784",
    "https://identifiers.org/mesh:D000069059",
    "https://identifiers.org/mesh:D008055"
  ],
  "mesh_chemical_pubtator_kw": [
    "cholesterol",
    "atorvastatin",
    "lipid"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D050197",
    "https://identifiers.org/mesh:D007249",
    "https://identifiers.org/mesh:D058226"
  ],
  "mesh_disease_pubtator_kw": [
    "atherosclerosis",
    "inflammatory",
    "Atherosclerotic plaque"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:3949"
  ],
  "mesh_gene_pubtator_kw": [
    "low-density lipoprotein receptor",
    "LDLR"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:9606"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "human"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS739",
  "study_findings": "Lipid metabolism downregulated under LSS; atorvastatin recapitulates HSS phenotype.",
  "study_observation": "Changes in endothelial cells under low and high shear stress.",
  "study_summary": "Lipid metabolism in HUVEC under shear stress.",
  "study_title_original": "Integrated Proteomics and Metabolomics Analysis Reveals Differential Lipid Metabolism in HUVEC under high and low shear stress"
}