Hfq Regulates Efflux Pump Expression and Purine Metabolic Pathway to Increase the Trimethoprim Resistance in Aeromonas veronii

Study details

Source ID

https://identifiers.org/metabolights:MTBLS1411

Title

Hfq Regulates Efflux Pump Expression and Purine Metabolic Pathway to Increase the Trimethoprim Resistance in Aeromonas veronii

Summary

Hfq increases trimethoprim resistance in A. veronii.

Observation

Hfq regulation of efflux pump expression and purine metabolism in A. veronii.

Findings

Hfq elevates efflux pump expression and degrades adenosine, guanosine to mediate trimethoprim resistance.

Disease terms

bacteremia, meningitis, dysentery, A. veronii infection

Gene terms

—

Chemical terms

trimethoprim, Purine, nitrogen, guanosine, adenosine, purine, Trimethoprim

Organisms

Aeromonas veronii, A. veronii, bacteriophage Qbeta

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS1411.

{
  "@type": "Dataset",
  "integmet_study": "MTBLS1411",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D014295",
    "https://identifiers.org/mesh:C030985",
    "https://identifiers.org/mesh:D009584",
    "https://identifiers.org/mesh:D006151",
    "https://identifiers.org/mesh:D000241"
  ],
  "mesh_chemical_pubtator_kw": [
    "trimethoprim",
    "Purine",
    "nitrogen",
    "guanosine",
    "adenosine",
    "purine",
    "Trimethoprim"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D016470",
    "https://identifiers.org/mesh:D008580",
    "https://identifiers.org/mesh:D004403",
    "https://identifiers.org/mesh:D007239"
  ],
  "mesh_disease_pubtator_kw": [
    "bacteremia",
    "meningitis",
    "dysentery",
    "A. veronii infection"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:654",
    "https://identifiers.org/taxonomy:39803"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "Aeromonas veronii",
    "A. veronii",
    "bacteriophage Qbeta"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS1411",
  "study_findings": "Hfq elevates efflux pump expression and degrades adenosine, guanosine to mediate trimethoprim resistance.",
  "study_observation": "Hfq regulation of efflux pump expression and purine metabolism in A. veronii.",
  "study_summary": "Hfq increases trimethoprim resistance in A. veronii.",
  "study_title_original": "Hfq Regulates Efflux Pump Expression and Purine Metabolic Pathway to Increase the Trimethoprim Resistance in Aeromonas veronii"
}