Metabolome analysis via an HPLC-ESI-MS-based experimental and computational pipeline for chronic nephron toxicity profiling

Study details

Source ID

https://identifiers.org/metabolights:MTBLS140

Title

Metabolome analysis via an HPLC-ESI-MS-based experimental and computational pipeline for chronic nephron toxicity profiling

Summary

Metabolome analysis for nephrotoxicity profiling using HPLC-ESI-MS.

Observation

Chronic nephrotoxicity in RPTEC/TERT1 cells treated with chloroacetaldehyde.

Findings

High concentration CAA treatment affects glutathione and oxidative stress response metabolites.

Disease terms

Nephron Toxicity, toxicity, cancer

Gene terms

ATF4, Nrf2

Chemical terms

glutathione, chloroacetaldehyde, ifosfamide

Organisms

human

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS140.

{
  "@type": "Dataset",
  "integmet_study": "MTBLS140",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D005978",
    "https://identifiers.org/mesh:C004656",
    "https://identifiers.org/mesh:D007069"
  ],
  "mesh_chemical_pubtator_kw": [
    "glutathione",
    "chloroacetaldehyde",
    "ifosfamide"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D030321",
    "https://identifiers.org/mesh:D064420",
    "https://identifiers.org/mesh:D009369"
  ],
  "mesh_disease_pubtator_kw": [
    "Nephron Toxicity",
    "toxicity",
    "cancer"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:468",
    "https://identifiers.org/ncbigene:4780"
  ],
  "mesh_gene_pubtator_kw": [
    "ATF4",
    "Nrf2"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:9606"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "human"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS140",
  "study_findings": "High concentration CAA treatment affects glutathione and oxidative stress response metabolites.",
  "study_observation": "Chronic nephrotoxicity in RPTEC/TERT1 cells treated with chloroacetaldehyde.",
  "study_summary": "Metabolome analysis for nephrotoxicity profiling using HPLC-ESI-MS.",
  "study_title_original": "Metabolome analysis via an HPLC-ESI-MS-based experimental and computational pipeline for chronic nephron toxicity profiling"
}