Diff Profiles › MTBLS1973_0001_00000002

G3_IDH1WT_U251_ER_Untreated_vs_G1_IDH1R132C_U251_ER_Untreated

IDH1WT_U251_ER_Untreated vs IDH1R132C_U251_ER_Untreated

p-value ≤ 0.05 2 significant 2025-09-26 00:00:00 Study: MTBLS1973
7 Total Features
2 Significant
0.05 p-value Threshold

Profile details

Identifier
MTBLS1973_0001_00000002
Linked study
MTBLS1973 — IDH1 Mutations Induce Organelle Defects Via Dysregulated Phospholipids (CSHNeg)
Comparison
IDH1WT_U251_ER_Untreated vs IDH1R132C_U251_ER_Untreated
Group A
U251 cells with wild-type IDH1 in the endoplasmic reticulum, untreated.. Provides baseline data for comparison with IDH1 mutant samples.
Group B
U251 cells with IDH1R132C mutation in the endoplasmic reticulum, untreated.. Helps in understanding the morphological changes in the ER due to IDH1R132C mutation.
Total features tested
7
Significant features
2
p-value threshold
0.05
Ratio threshold (upper)
1.5
Ratio threshold (lower)
1/1.5
Date created
2025-09-26 00:00:00

Top hits

Metabolite ID (InChI Key) Name Direction Ratio p-value
OTTXIFWBPRRYOG-UHFFFAOYSA-N 2-Hydroxyadipate down 0.3095 0.00101
JAZBEHYOTPTENJ-JLNKQSITSA-N 5,8,11,14,17-EICOSAPENTAENOIC ACID down 0.6619 0.0127