IDH1 Mutations Induce Organelle Defects Via Dysregulated Phospholipids (CSHNeg)

Study details

Source ID

https://identifiers.org/metabolights:MTBLS1973

Title

IDH1 Mutations Induce Organelle Defects Via Dysregulated Phospholipids (CSHNeg)

Summary

IDH1 mutations affect organelle morphology via lipid imbalance.

Observation

Monounsaturated to polyunsaturated lipid imbalances in organelles due to IDH mutation.

Findings

IDH1 mutation causes organelle defects via SCD overexpression; oleic acid induces apoptosis in IDH1mut cells.

Disease terms

tumors, glioma, gliomas, tumor

Gene terms

stearyl-CoA desaturase, SCD, IDH1, IDH1WT

Chemical terms

D-2HG, oleic acid, lipid, MUFA, lipids, phospholipids, monounsaturated fatty acids

Organisms

—

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS1973.

{
  "@type": "Dataset",
  "integmet_study": "MTBLS1973",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:C019417",
    "https://identifiers.org/mesh:D019301",
    "https://identifiers.org/mesh:D008055",
    "https://identifiers.org/mesh:D005229",
    "https://identifiers.org/mesh:D010743"
  ],
  "mesh_chemical_pubtator_kw": [
    "D-2HG",
    "oleic acid",
    "lipid",
    "MUFA",
    "lipids",
    "phospholipids",
    "monounsaturated fatty acids"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D009369",
    "https://identifiers.org/mesh:D005910"
  ],
  "mesh_disease_pubtator_kw": [
    "tumors",
    "glioma",
    "gliomas",
    "tumor"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:6319",
    "https://identifiers.org/ncbigene:3417"
  ],
  "mesh_gene_pubtator_kw": [
    "stearyl-CoA desaturase",
    "SCD",
    "IDH1",
    "IDH1WT"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS1973",
  "study_findings": "IDH1 mutation causes organelle defects via SCD overexpression; oleic acid induces apoptosis in IDH1mut cells.",
  "study_observation": "Monounsaturated to polyunsaturated lipid imbalances in organelles due to IDH mutation.",
  "study_summary": "IDH1 mutations affect organelle morphology via lipid imbalance.",
  "study_title_original": "IDH1 Mutations Induce Organelle Defects Via Dysregulated Phospholipids (CSHNeg)"
}