IDH1 Mutations Induce Organelle Defects Via Dysregulated Phospholipids (FA_HILICZ)

Study details

Source ID

https://identifiers.org/metabolights:MTBLS1967

Title

IDH1 Mutations Induce Organelle Defects Via Dysregulated Phospholipids (FA_HILICZ)

Summary

IDH1 mutations affect organelle morphology via lipid imbalance.

Observation

IDH1 mutation effects on organelle lipid distribution in gliomas.

Findings

IDH1mut-induced SCD overexpression alters lipid distribution, affecting organelle morphology.

Disease terms

tumors, glioma, gliomas, tumor

Gene terms

stearyl-CoA desaturase, SCD, IDH1, IDH1WT

Chemical terms

D-2HG, oleic acid, lipid, MUFA, lipids, phospholipids, monounsaturated fatty acids

Organisms

—

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS1967.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0005737",
    "https://identifiers.org/GO:0006915",
    "https://identifiers.org/GO:0008610",
    "https://identifiers.org/GO:0006629",
    "https://identifiers.org/GO:0005783"
  ],
  "go_kw": [
    "cytoplasm",
    "apoptosis",
    "lipid biosynthesis",
    "lipid metabolism",
    "ER"
  ],
  "integmet_study": "MTBLS1967",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:C019417",
    "https://identifiers.org/mesh:D019301",
    "https://identifiers.org/mesh:D008055",
    "https://identifiers.org/mesh:D005229",
    "https://identifiers.org/mesh:D010743"
  ],
  "mesh_chemical_pubtator_kw": [
    "D-2HG",
    "oleic acid",
    "lipid",
    "MUFA",
    "lipids",
    "phospholipids",
    "monounsaturated fatty acids"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D009369",
    "https://identifiers.org/mesh:D005910"
  ],
  "mesh_disease_pubtator_kw": [
    "tumors",
    "glioma",
    "gliomas",
    "tumor"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:6319",
    "https://identifiers.org/ncbigene:3417"
  ],
  "mesh_gene_pubtator_kw": [
    "stearyl-CoA desaturase",
    "SCD",
    "IDH1",
    "IDH1WT"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS1967",
  "study_findings": "IDH1mut-induced SCD overexpression alters lipid distribution, affecting organelle morphology.",
  "study_observation": "IDH1 mutation effects on organelle lipid distribution in gliomas.",
  "study_summary": "IDH1 mutations affect organelle morphology via lipid imbalance.",
  "study_title_original": "IDH1 Mutations Induce Organelle Defects Via Dysregulated Phospholipids (FA_HILICZ)"
}