IDH1 Mutations Induce Organelle Defects Via Dysregulated Phospholipids (CSHpos)

Study details

Source ID

https://identifiers.org/metabolights:MTBLS1974

Title

IDH1 Mutations Induce Organelle Defects Via Dysregulated Phospholipids (CSHpos)

Summary

IDH1 mutations cause organelle defects via lipid imbalance.

Observation

Monounsaturated to polyunsaturated lipid imbalances in organelles.

Findings

IDH1 mutation-induced SCD overexpression alters lipid distribution, affecting organelle morphology.

Disease terms

tumors, glioma, gliomas, tumor

Gene terms

stearyl-CoA desaturase, SCD, IDH1, IDH1WT

Chemical terms

D-2HG, oleic acid, lipid, MUFA, lipids, phospholipids, monounsaturated fatty acids

Organisms

—

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS1974.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0006633",
    "https://identifiers.org/GO:0005737",
    "https://identifiers.org/GO:0006915",
    "https://identifiers.org/GO:0005783",
    "https://identifiers.org/GO:0008610",
    "https://identifiers.org/GO:0006629",
    "https://identifiers.org/GO:0008219"
  ],
  "go_kw": [
    "fatty acid biosynthesis",
    "cytoplasm",
    "apoptosis",
    "endoplasmic reticulum",
    "lipid biosynthesis",
    "lipid metabolism",
    "cell death"
  ],
  "integmet_study": "MTBLS1974",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:C019417",
    "https://identifiers.org/mesh:D019301",
    "https://identifiers.org/mesh:D008055",
    "https://identifiers.org/mesh:D005229",
    "https://identifiers.org/mesh:D010743"
  ],
  "mesh_chemical_pubtator_kw": [
    "D-2HG",
    "oleic acid",
    "lipid",
    "MUFA",
    "lipids",
    "phospholipids",
    "monounsaturated fatty acids"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D009369",
    "https://identifiers.org/mesh:D005910"
  ],
  "mesh_disease_pubtator_kw": [
    "tumors",
    "glioma",
    "gliomas",
    "tumor"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:6319",
    "https://identifiers.org/ncbigene:3417"
  ],
  "mesh_gene_pubtator_kw": [
    "stearyl-CoA desaturase",
    "SCD",
    "IDH1",
    "IDH1WT"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS1974",
  "study_findings": "IDH1 mutation-induced SCD overexpression alters lipid distribution, affecting organelle morphology.",
  "study_observation": "Monounsaturated to polyunsaturated lipid imbalances in organelles.",
  "study_summary": "IDH1 mutations cause organelle defects via lipid imbalance.",
  "study_title_original": "IDH1 Mutations Induce Organelle Defects Via Dysregulated Phospholipids (CSHpos)"
}