crizotinib

Metabolite details

Identifier: KTEIFNKAUNYNJU-GFCCVEGCSA-N
InChI Key: KTEIFNKAUNYNJU-GFCCVEGCSA-N
IUPAC name: 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine
Preferred name: crizotinib
INN name: crizotinib
Synonym: PF 2341066
ChEBI: CHEBI:64310

R-HSA-162582 - Signal Transduction
R-HSA-1643685 - Disease
R-HSA-201556 - Signaling by ALK
R-HSA-5663202 - Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-6806834 - Signaling by MET
R-HSA-6806942 - MET Receptor Activation
R-HSA-6807004 - Negative regulation of MET activity
R-HSA-9006934 - Signaling by Receptor Tyrosine Kinases
R-HSA-9700206 - Signaling by ALK in cancer
R-HSA-9700645 - ALK mutants bind TKIs
R-HSA-9700649 - Drug resistance of ALK mutants
R-HSA-9717326 - crizotinib-resistant ALK mutants
R-HSA-9725370 - Signaling by ALK fusions and activated point mutants
R-HSA-9725371 - Nuclear events stimulated by ALK signaling in cancer
R-HSA-9734091 - Drug-mediated inhibition of MET activation