celastrol

Metabolite details

Identifier

KQJSQWZMSAGSHN-JJWQIEBTSA-N

InChI Key

KQJSQWZMSAGSHN-JJWQIEBTSA-N

IUPAC name

(2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid

Preferred name

celastrol

INN name

—

Synonym

D:A-Friedo-24-noroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-2-oxo-, (20alpha)-

ChEBI

CHEBI:63959

Reactome pathways

• No Reactome pathways listed for this metabolite.

Observed in studies

• The genome analysis of Tripterygium wilfordii reveals TwCYP712K1 and TwCYP712K2 responsible for oxidation of friedelin in celastrol biosynthesis pathway
• Metabolomics analysis identifies metabolites associated with systemic acquired resistance in Arabidopsis
• Metabolic Dynamics of In Vitro CD8+ T Cell Activation.
• Metabolomic Insights into the Browning of the Peel of Bagging ‘Rui Xue’ Apple Fruit
• Diallyl disulfide (DADS) ameliorates intestinal Candida albicans infection by modulating the gut microbiota and metabolites and providing intestinal protection in mice
• Metabolic profilings of rat INS-1 β-cells under changing levels of essential amino acids
• Effects of Radiofrequency Field from 5G Communications on fecal microbiome and metabolome profiles in mice

Observed in differential profiles

• Root_vs_Young_Leaf
• Local_Leaf_Control_vs_Local_Leaf_Avr
• G3_Experimental_Sample_0h_vs_G11_Experimental_Sample_96h
• Non_Bagged_Fruits_vs_Bagged_Fruits_With_Browning
• G1_PBS_vs_G2_DSS
• G1_Control_vs_G2_Arginine_Addition
• Sham_vs_Radiofrequency