Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease

Study details

Source ID

https://identifiers.org/metabolights:MTBLS6982

Title

Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease

Summary

Palmitic acid linked to congenital heart disease.

Observation

Palmitic acid concentration in pregnant women and mice.

Findings

Palmitic acid increases CHD risk; K-Hcy targeting reduces CHD onset.

Disease terms

abnormal heart development, CHD, maternal malnutrition, congenital heart disease

Gene terms

MARS, Mars, GATA4, GATA-binding protein 4

Chemical terms

lysine, N-acetyl-L-cysteine, PA, NAC, fatty acid, palmitic acid, folic acid

Organisms

women, mice

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS6982.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0006631",
    "https://identifiers.org/GO:0005634",
    "https://identifiers.org/GO:0007507"
  ],
  "go_kw": [
    "fatty acid metabolism",
    "nucleus",
    "heart development"
  ],
  "integmet_study": "MTBLS6982",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D008239",
    "https://identifiers.org/mesh:D000111",
    "https://identifiers.org/mesh:D019308",
    "https://identifiers.org/mesh:D005227",
    "https://identifiers.org/mesh:D005492"
  ],
  "mesh_chemical_pubtator_kw": [
    "lysine",
    "N-acetyl-L-cysteine",
    "PA",
    "NAC",
    "fatty acid",
    "palmitic acid",
    "folic acid"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D002658",
    "https://identifiers.org/mesh:D006330",
    "https://identifiers.org/mesh:D044342"
  ],
  "mesh_disease_pubtator_kw": [
    "abnormal heart development",
    "CHD",
    "maternal malnutrition",
    "congenital heart disease"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:216443",
    "https://identifiers.org/ncbigene:14463",
    "https://identifiers.org/ncbigene:2626"
  ],
  "mesh_gene_pubtator_kw": [
    "MARS",
    "Mars",
    "GATA4",
    "GATA-binding protein 4"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:9606",
    "https://identifiers.org/taxonomy:10090"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "women",
    "mice"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS6982",
  "study_findings": "Palmitic acid increases CHD risk; K-Hcy targeting reduces CHD onset.",
  "study_observation": "Palmitic acid concentration in pregnant women and mice.",
  "study_summary": "Palmitic acid linked to congenital heart disease.",
  "study_title_original": "Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease"
}