Bacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway.

Study details

Source ID

https://identifiers.org/metabolights:MTBLS696

Title

Bacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway.

Summary

Pathogens activate reverse transsulfuration in macrophages.

Observation

Induction of cystathionine γ-lyase (CTH) in macrophages by bacteria.

Findings

CTH expression disrupts macrophage activation, aiding pathogen survival.

Disease terms

—

Gene terms

CTH, cystathionine gamma-lyase, phosphatidylinositol 3-kinase, MTOR

Chemical terms

polyamines, sulfur, polyamine, putrescine, cystathionine, spermidine, S-adenosylmethionine, spermine

Organisms

—

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS696.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0005737",
    "https://identifiers.org/GO:0008152",
    "https://identifiers.org/GO:0009058",
    "https://identifiers.org/GO:0006595",
    "https://identifiers.org/GO:0005634",
    "https://identifiers.org/GO:0042116",
    "https://identifiers.org/GO:0006351",
    "https://identifiers.org/GO:0023052",
    "https://identifiers.org/GO:0032259",
    "https://identifiers.org/GO:0006955"
  ],
  "go_kw": [
    "cytoplasm",
    "metabolism",
    "synthesis",
    "polyamine metabolism",
    "nucleus",
    "macrophage activation",
    "transcription",
    "signaling",
    "methylation",
    "immune response"
  ],
  "integmet_study": "MTBLS696",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D011073",
    "https://identifiers.org/mesh:D013455",
    "https://identifiers.org/mesh:D011700",
    "https://identifiers.org/mesh:D003540",
    "https://identifiers.org/mesh:D013095",
    "https://identifiers.org/mesh:D012436",
    "https://identifiers.org/mesh:D013096"
  ],
  "mesh_chemical_pubtator_kw": [
    "polyamines",
    "sulfur",
    "polyamine",
    "putrescine",
    "cystathionine",
    "spermidine",
    "S-adenosylmethionine",
    "spermine"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:1491",
    "https://identifiers.org/ncbigene:5295",
    "https://identifiers.org/ncbigene:2475"
  ],
  "mesh_gene_pubtator_kw": [
    "CTH",
    "cystathionine gamma-lyase",
    "phosphatidylinositol 3-kinase",
    "MTOR"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS696",
  "study_findings": "CTH expression disrupts macrophage activation, aiding pathogen survival.",
  "study_observation": "Induction of cystathionine \u03b3-lyase (CTH) in macrophages by bacteria.",
  "study_summary": "Pathogens activate reverse transsulfuration in macrophages.",
  "study_title_original": "Bacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway."
}