Untargeted metabolomics to understand the basis of phenotypic differences in amphotericin B-resistant Leishmania parasites

Study details

Source ID

https://identifiers.org/metabolights:MTBLS1167

Title

Untargeted metabolomics to understand the basis of phenotypic differences in amphotericin B-resistant Leishmania parasites

Summary

Metabolomics study on AmB-resistant Leishmania phenotypic differences.

Observation

Metabolite abundance differences in AmB-resistant Leishmania lines.

Findings

Metabolic changes may influence phenotypic profiles beyond drug resistance.

Disease terms

infections, Leishmania infection

Gene terms

—

Chemical terms

trypanothione, sterol, AmB, Amphotericin B, amphotericin B, carbon, glutathione

Organisms

L. mexicana, Leishmania

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS1167.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0009406",
    "https://identifiers.org/GO:0008152"
  ],
  "go_kw": [
    "virulence",
    "metabolism"
  ],
  "integmet_study": "MTBLS1167",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:C044809",
    "https://identifiers.org/mesh:D013261",
    "https://identifiers.org/mesh:D000666",
    "https://identifiers.org/mesh:D002244",
    "https://identifiers.org/mesh:D005978"
  ],
  "mesh_chemical_pubtator_kw": [
    "trypanothione",
    "sterol",
    "AmB",
    "Amphotericin B",
    "amphotericin B",
    "carbon",
    "glutathione"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D007239",
    "https://identifiers.org/mesh:D007896"
  ],
  "mesh_disease_pubtator_kw": [
    "infections",
    "Leishmania infection"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:5665",
    "https://identifiers.org/taxonomy:38568"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "L. mexicana",
    "Leishmania"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS1167",
  "study_findings": "Metabolic changes may influence phenotypic profiles beyond drug resistance.",
  "study_observation": "Metabolite abundance differences in AmB-resistant Leishmania lines.",
  "study_summary": "Metabolomics study on AmB-resistant Leishmania phenotypic differences.",
  "study_title_original": "Untargeted metabolomics to understand the basis of phenotypic differences in amphotericin B-resistant Leishmania parasites"
}