Gut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy

Study details

Source ID

https://identifiers.org/metabolights:MTBLS3174

Title

Gut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy

Summary

TMAVA affects cardiac hypertrophy via carnitine inhibition.

Observation

Gut microbiota production of TMAVA and its effects on cardiac hypertrophy.

Findings

TMAVA inhibits carnitine synthesis, reducing FAO and accelerating cardiac hypertrophy.

Disease terms

diseased heart, heart failure, cardiac hypertrophy, cardiac hypertrophy and dysfunction, contractile dysfunction

Gene terms

gamma-butyrobetaine hydroxylase

Chemical terms

carnitine, lipid, TMAVA, N,N,N-trimethyl-5-aminovaleric acid, fatty acid, trimethyllysine

Organisms

mice, Mice

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS3174.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0019395",
    "https://identifiers.org/GO:0009437",
    "https://identifiers.org/GO:0046322"
  ],
  "go_kw": [
    "fatty acid oxidation (FAO)",
    "carnitine metabolism",
    "inhibition of fatty acid oxidation (FAO)"
  ],
  "integmet_study": "MTBLS3174",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D002331",
    "https://identifiers.org/mesh:D008055",
    "https://identifiers.org/mesh:C000713634",
    "https://identifiers.org/mesh:D005227",
    "https://identifiers.org/mesh:C003712"
  ],
  "mesh_chemical_pubtator_kw": [
    "carnitine",
    "lipid",
    "TMAVA",
    "N,N,N-trimethyl-5-aminovaleric acid",
    "fatty acid",
    "trimethyllysine"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D006331",
    "https://identifiers.org/mesh:D006333",
    "https://identifiers.org/mesh:D006332"
  ],
  "mesh_disease_pubtator_kw": [
    "diseased heart",
    "heart failure",
    "cardiac hypertrophy",
    "cardiac hypertrophy and dysfunction",
    "contractile dysfunction"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:170442"
  ],
  "mesh_gene_pubtator_kw": [
    "gamma-butyrobetaine hydroxylase"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:10090"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "mice",
    "Mice"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS3174",
  "study_findings": "TMAVA inhibits carnitine synthesis, reducing FAO and accelerating cardiac hypertrophy.",
  "study_observation": "Gut microbiota production of TMAVA and its effects on cardiac hypertrophy.",
  "study_summary": "TMAVA affects cardiac hypertrophy via carnitine inhibition.",
  "study_title_original": "Gut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy"
}