SARS-CoV-2-reprogrammed metabolism and autophagy reduction uncover host-targeting antivirals

Study details

Source ID

https://identifiers.org/metabolights:MTBLS2840

Title

SARS-CoV-2-reprogrammed metabolism and autophagy reduction uncover host-targeting antivirals

Summary

SARS-CoV-2 affects metabolism and autophagy.

Observation

SARS-CoV-2 modulates metabolism and reduces autophagy in cells.

Findings

Autophagy-inducing compounds inhibit SARS-CoV-2 propagation in vitro.

Disease terms

autoimmune, SARS-CoV-2, SARS-CoV-2-infected, COVID-19, long COVID-19, inflammatory

Gene terms

TSC2, P62, AKT1, AMPK, VPS34, ULK1, SKP2, BECN1, ATG14

Chemical terms

spermine, MK-2206, spermidine, niclosamide

Organisms

hamster, human, patients, patient, SARS-CoV-2

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS2840.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0005737",
    "https://identifiers.org/GO:0016310",
    "https://identifiers.org/GO:0061908",
    "https://identifiers.org/GO:0061909",
    "https://identifiers.org/GO:0006954",
    "https://identifiers.org/GO:0006914",
    "https://identifiers.org/GO:0044237",
    "https://identifiers.org/GO:0006955",
    "https://identifiers.org/GO:0005776"
  ],
  "go_kw": [
    "cytoplasm",
    "phosphorylation",
    "phagophore",
    "autophagosome-lysosome fusion",
    "inflammatory response",
    "autophagy",
    "cellular metabolism",
    "immune response",
    "autophagosome"
  ],
  "integmet_study": "MTBLS2840",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D013096",
    "https://identifiers.org/mesh:C548887",
    "https://identifiers.org/mesh:D013095",
    "https://identifiers.org/mesh:D009534"
  ],
  "mesh_chemical_pubtator_kw": [
    "spermine",
    "MK-2206",
    "spermidine",
    "niclosamide"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D001327",
    "https://identifiers.org/mesh:D000086382",
    "https://identifiers.org/mesh:D000094024",
    "https://identifiers.org/mesh:D007249"
  ],
  "mesh_disease_pubtator_kw": [
    "autoimmune",
    "SARS-CoV-2",
    "SARS-CoV-2-infected",
    "COVID-19",
    "long COVID-19",
    "inflammatory"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:7249",
    "https://identifiers.org/ncbigene:23636",
    "https://identifiers.org/ncbigene:207",
    "https://identifiers.org/ncbigene:5562",
    "https://identifiers.org/ncbigene:5289",
    "https://identifiers.org/ncbigene:8408",
    "https://identifiers.org/ncbigene:6502",
    "https://identifiers.org/ncbigene:8678",
    "https://identifiers.org/ncbigene:22863"
  ],
  "mesh_gene_pubtator_kw": [
    "TSC2",
    "P62",
    "AKT1",
    "AMPK",
    "VPS34",
    "ULK1",
    "SKP2",
    "BECN1",
    "ATG14"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:10034",
    "https://identifiers.org/taxonomy:9606",
    "https://identifiers.org/taxonomy:2697049"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "hamster",
    "human",
    "patients",
    "patient",
    "SARS-CoV-2"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS2840",
  "study_findings": "Autophagy-inducing compounds inhibit SARS-CoV-2 propagation in vitro.",
  "study_observation": "SARS-CoV-2 modulates metabolism and reduces autophagy in cells.",
  "study_summary": "SARS-CoV-2 affects metabolism and autophagy.",
  "study_title_original": "SARS-CoV-2-reprogrammed metabolism and autophagy reduction uncover host-targeting antivirals"
}