Searching for Drug Synergy Against Cancer Through Polyamine Metabolism Impairment: Insight Into the Metabolic Effect of Indomethacin on Lung Cancer Cells.

Study details

Source ID

https://identifiers.org/metabolights:MTBLS873

Title

Searching for Drug Synergy Against Cancer Through Polyamine Metabolism Impairment: Insight Into the Metabolic Effect of Indomethacin on Lung Cancer Cells.

Summary

Indomethacin affects polyamine metabolism in NSCLC cells.

Observation

Effect of indomethacin on NSCLC cell lines A549 and H1299.

Findings

Indomethacin alters polyamine metabolism and enhances polyamine synthesis inhibitors' effects in NSCLC cells.

Disease terms

Lung Cancer, NSCLC, inflammatory, cancer, Cancer, tumor, Non-small cell lung cancer, lung cancer

Gene terms

ornithine decarboxylase, spermidine/spermine-N1-acetyltransferase, spermine oxidase, polyamine oxidase, SAT1, SSAT

Chemical terms

polyamines, indomethacin, eflornithine, polyamine, putrescine, MDL72527, ornithine, spermidine, Polyamine, Indomethacin, spermine, methionine, urea

Organisms

—

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS873.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0000050",
    "https://identifiers.org/GO:0006596",
    "https://identifiers.org/GO:0006595"
  ],
  "go_kw": [
    "urea cycle",
    "polyamine synthesis",
    "polyamine metabolism"
  ],
  "integmet_study": "MTBLS873",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D011073",
    "https://identifiers.org/mesh:D007213",
    "https://identifiers.org/mesh:D000518",
    "https://identifiers.org/mesh:D011700",
    "https://identifiers.org/mesh:C044445",
    "https://identifiers.org/mesh:D009952",
    "https://identifiers.org/mesh:D013095",
    "https://identifiers.org/mesh:D013096",
    "https://identifiers.org/mesh:D008715",
    "https://identifiers.org/mesh:D014508"
  ],
  "mesh_chemical_pubtator_kw": [
    "polyamines",
    "indomethacin",
    "eflornithine",
    "polyamine",
    "putrescine",
    "MDL72527",
    "ornithine",
    "spermidine",
    "Polyamine",
    "Indomethacin",
    "spermine",
    "methionine",
    "urea"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D008175",
    "https://identifiers.org/mesh:D002289",
    "https://identifiers.org/mesh:D007249",
    "https://identifiers.org/mesh:D009369"
  ],
  "mesh_disease_pubtator_kw": [
    "Lung Cancer",
    "NSCLC",
    "inflammatory",
    "cancer",
    "Cancer",
    "tumor",
    "Non-small cell lung cancer",
    "lung cancer"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:4953",
    "https://identifiers.org/ncbigene:6303",
    "https://identifiers.org/ncbigene:54498",
    "https://identifiers.org/ncbigene:196743"
  ],
  "mesh_gene_pubtator_kw": [
    "ornithine decarboxylase",
    "spermidine/spermine-N1-acetyltransferase",
    "spermine oxidase",
    "polyamine oxidase",
    "SAT1",
    "SSAT"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS873",
  "study_findings": "Indomethacin alters polyamine metabolism and enhances polyamine synthesis inhibitors\u0027 effects in NSCLC cells.",
  "study_observation": "Effect of indomethacin on NSCLC cell lines A549 and H1299.",
  "study_summary": "Indomethacin affects polyamine metabolism in NSCLC cells.",
  "study_title_original": "Searching for Drug Synergy Against Cancer Through Polyamine Metabolism Impairment: Insight Into the Metabolic Effect of Indomethacin on Lung Cancer Cells."
}