Global Analyses of Selective Insulin Resistance in Hepatocytes due to Palmitate Lipotoxicity

Study details

Source ID

https://identifiers.org/metabolights:MTBLS582

Title

Global Analyses of Selective Insulin Resistance in Hepatocytes due to Palmitate Lipotoxicity

Summary

Selective insulin resistance in hepatocytes by palmitate.

Observation

Phosphoproteome of insulin treated human hepatoma cells.

Findings

Palmitate impairs insulin signaling to FoxO1, affecting gluconeogenesis.

Disease terms

insulin resistance, Insulin Resistance, hepatoma, hepatic steatosis, Obesity

Gene terms

insulin, FoxO1

Chemical terms

lipid, palmitate

Organisms

human

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS582.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0006094",
    "https://identifiers.org/GO:0008610"
  ],
  "go_kw": [
    "gluconeogenesis",
    "lipid synthesis"
  ],
  "integmet_study": "MTBLS582",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D008055",
    "https://identifiers.org/mesh:D010168"
  ],
  "mesh_chemical_pubtator_kw": [
    "lipid",
    "palmitate"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D007333",
    "https://identifiers.org/mesh:D006528",
    "https://identifiers.org/mesh:D005234",
    "https://identifiers.org/mesh:D009765"
  ],
  "mesh_disease_pubtator_kw": [
    "insulin resistance",
    "Insulin Resistance",
    "hepatoma",
    "hepatic steatosis",
    "Obesity"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:3630",
    "https://identifiers.org/ncbigene:2308"
  ],
  "mesh_gene_pubtator_kw": [
    "insulin",
    "FoxO1"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:9606"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "human"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS582",
  "study_findings": "Palmitate impairs insulin signaling to FoxO1, affecting gluconeogenesis.",
  "study_observation": "Phosphoproteome of insulin treated human hepatoma cells.",
  "study_summary": "Selective insulin resistance in hepatocytes by palmitate.",
  "study_title_original": "Global Analyses of Selective Insulin Resistance in Hepatocytes due to Palmitate Lipotoxicity"
}