Sodium Butyrate mediates Histone Crotonylation and Alleviated Neonatal Rats Hypoxic-Ischemic Brain Injury Through Gut-Brain Axis (targeted SCFA brain metabolomics)

Study details

Source ID

https://identifiers.org/metabolights:MTBLS4933

Title

Sodium Butyrate mediates Histone Crotonylation and Alleviated Neonatal Rats Hypoxic-Ischemic Brain Injury Through Gut-Brain Axis (targeted SCFA brain metabolomics)

Summary

Sodium butyrate affects histone crotonylation in HIBD rats.

Observation

Neonatal HIBD rats' butanoate metabolism and SCFAs-producing bacteria levels.

Findings

Sodium butyrate ameliorates HIBD via gut microbiota and histone crotonylation.

Disease terms

hypoxia, hypoxic-ischemic brain damage, pathological damage, Neonatal hypoxic-ischemic encephalopathy, ischemic brain injury, nervous system damage, HIE, hypoxic, neuro-developmental disorders, HIBD

Gene terms

Cdnf, Bdnf, ACADS, Manf, histone, Gdnf

Chemical terms

short chain fatty acid, SB, SCFAs, butyrate, Sodium butyrate, crotonyl-CoA

Organisms

rats

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS4933.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0005739",
    "https://identifiers.org/GO:0007399"
  ],
  "go_kw": [
    "mitochondrion",
    "nervous system development"
  ],
  "integmet_study": "MTBLS4933",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D005232",
    "https://identifiers.org/mesh:D020148",
    "https://identifiers.org/mesh:D002087",
    "https://identifiers.org/mesh:C010701"
  ],
  "mesh_chemical_pubtator_kw": [
    "short chain fatty acid",
    "SB",
    "SCFAs",
    "butyrate",
    "Sodium butyrate",
    "crotonyl-CoA"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D000860",
    "https://identifiers.org/mesh:D002534",
    "https://identifiers.org/mesh:D005598",
    "https://identifiers.org/mesh:D020925",
    "https://identifiers.org/mesh:D001930",
    "https://identifiers.org/mesh:D020196",
    "https://identifiers.org/mesh:C536203"
  ],
  "mesh_disease_pubtator_kw": [
    "hypoxia",
    "hypoxic-ischemic brain damage",
    "pathological damage",
    "Neonatal hypoxic-ischemic encephalopathy",
    "ischemic brain injury",
    "nervous system damage",
    "HIE",
    "hypoxic",
    "neuro-developmental disorders",
    "HIBD"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:361276",
    "https://identifiers.org/ncbigene:24225",
    "https://identifiers.org/ncbigene:64304",
    "https://identifiers.org/ncbigene:315989",
    "https://identifiers.org/ncbigene:24829",
    "https://identifiers.org/ncbigene:25453"
  ],
  "mesh_gene_pubtator_kw": [
    "Cdnf",
    "Bdnf",
    "ACADS",
    "Manf",
    "histone",
    "Gdnf"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:10116"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "rats"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS4933",
  "study_findings": "Sodium butyrate ameliorates HIBD via gut microbiota and histone crotonylation.",
  "study_observation": "Neonatal HIBD rats\u0027 butanoate metabolism and SCFAs-producing bacteria levels.",
  "study_summary": "Sodium butyrate affects histone crotonylation in HIBD rats.",
  "study_title_original": "Sodium Butyrate mediates Histone Crotonylation and Alleviated Neonatal Rats Hypoxic-Ischemic Brain Injury Through Gut-Brain Axis (targeted SCFA brain metabolomics)"
}