TFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis.

Study details

Source ID

https://identifiers.org/metabolights:MTBLS4307

Title

TFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis.

Summary

TFAM loss promotes liver cancer metastasis.

Observation

TFAM deficiency, nuclear actin polymerization, mDia2 malonylation, liver cancer metastasis

Findings

TFAM loss induces nuclear actin assembly, promoting liver cancer metastasis via mitochondria-to-nucleus signaling.

Disease terms

HCC metastasis, cancer metastasis, liver cancer metastasis, lung metastasis, metastasis of, tumor, HCC, liver cancer

Gene terms

mDia2, TFAM

Chemical terms

malonyl-CoA, TCA

Organisms

patients, mice

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS4307.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0005856",
    "https://identifiers.org/GO:0005739",
    "https://identifiers.org/GO:0001525",
    "https://identifiers.org/GO:0005634",
    "https://identifiers.org/GO:0006099",
    "https://identifiers.org/GO:0016477"
  ],
  "go_kw": [
    "cytoskeleton",
    "mitochondria",
    "angiogenesis",
    "nucleus",
    "TCA cycle",
    "cell migration"
  ],
  "integmet_study": "MTBLS4307",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D008316",
    "https://identifiers.org/mesh:D014238"
  ],
  "mesh_chemical_pubtator_kw": [
    "malonyl-CoA",
    "TCA"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D006528",
    "https://identifiers.org/mesh:D009369",
    "https://identifiers.org/mesh:D009362"
  ],
  "mesh_disease_pubtator_kw": [
    "HCC metastasis",
    "cancer metastasis",
    "liver cancer metastasis",
    "lung metastasis",
    "metastasis of",
    "tumor",
    "HCC",
    "liver cancer"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:56419",
    "https://identifiers.org/ncbigene:21780",
    "https://identifiers.org/ncbigene:7019"
  ],
  "mesh_gene_pubtator_kw": [
    "mDia2",
    "TFAM"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:9606",
    "https://identifiers.org/taxonomy:10090"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "patients",
    "mice"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS4307",
  "study_findings": "TFAM loss induces nuclear actin assembly, promoting liver cancer metastasis via mitochondria-to-nucleus signaling.",
  "study_observation": "TFAM deficiency, nuclear actin polymerization, mDia2 malonylation, liver cancer metastasis",
  "study_summary": "TFAM loss promotes liver cancer metastasis.",
  "study_title_original": "TFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis."
}