Cell Membrane Remodeling Mediates Polymyxin B Resistance in <i>Klebsiella pneumoniae</i>: An Integrated Proteomics and Metabolomics Study.

Study details

Source ID

https://identifiers.org/metabolights:MTBLS4132

Title

Cell Membrane Remodeling Mediates Polymyxin B Resistance in <i>Klebsiella pneumoniae</i>: An Integrated Proteomics and Metabolomics Study.

Summary

Polymyxin B resistance mechanisms in Klebsiella pneumoniae.

Observation

Polymyxin B resistance in Klebsiella pneumoniae.

Findings

Membrane remodeling and inhibited central carbon metabolism contribute to resistance.

Disease terms

Klebsiella pneumoniae, CRKP

Gene terms

—

Chemical terms

LPS, carbapenem, ROS, crystal violet, reactive oxygen species, sphingolipids, fatty acids, lipids, carbon, glycerophospholipids

Organisms

K. pneumoniae, Klebsiella pneumoniae

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS4132.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0140359",
    "https://identifiers.org/GO:0042710",
    "https://identifiers.org/GO:0015914"
  ],
  "go_kw": [
    "ABC transporters",
    "biofilm formation",
    "phospholipid transport"
  ],
  "integmet_study": "MTBLS4132",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D008070",
    "https://identifiers.org/mesh:D015780",
    "https://identifiers.org/mesh:D017382",
    "https://identifiers.org/mesh:D005840",
    "https://identifiers.org/mesh:D013107",
    "https://identifiers.org/mesh:D005227",
    "https://identifiers.org/mesh:D008055",
    "https://identifiers.org/mesh:D002244",
    "https://identifiers.org/mesh:D020404"
  ],
  "mesh_chemical_pubtator_kw": [
    "LPS",
    "carbapenem",
    "ROS",
    "crystal violet",
    "reactive oxygen species",
    "sphingolipids",
    "fatty acids",
    "lipids",
    "carbon",
    "glycerophospholipids"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D007710"
  ],
  "mesh_disease_pubtator_kw": [
    "Klebsiella pneumoniae",
    "CRKP"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:573"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "K. pneumoniae",
    "Klebsiella pneumoniae"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS4132",
  "study_findings": "Membrane remodeling and inhibited central carbon metabolism contribute to resistance.",
  "study_observation": "Polymyxin B resistance in Klebsiella pneumoniae.",
  "study_summary": "Polymyxin B resistance mechanisms in Klebsiella pneumoniae.",
  "study_title_original": "Cell Membrane Remodeling Mediates Polymyxin B Resistance in \u003ci\u003eKlebsiella pneumoniae\u003c/i\u003e: An Integrated Proteomics and Metabolomics Study."
}