Integrated Analyses of the Gut Microbiota, Intestinal Permeability and Serum Metabolome Phenotype in Rats with Alcohol Withdrawal Syndrome

Study details

Source ID

https://identifiers.org/metabolights:MTBLS2688

Title

Integrated Analyses of the Gut Microbiota, Intestinal Permeability and Serum Metabolome Phenotype in Rats with Alcohol Withdrawal Syndrome

Summary

Alcohol affects gut microbiota and serum metabolites.

Observation

Gut microbiota, intestinal permeability, serum metabolic profile in alcohol-dependent rats.

Findings

Alcohol alters gut microbiota, increases permeability, affects serum metabolites and neurotransmitter homeostasis.

Disease terms

alcohol abuse, psychiatric disorders, neurotransmitter disorders, Alcohol Withdrawal Syndrome, microbiota dysbiosis, alcoholism, gut leakiness, alcohol dependence

Gene terms

—

Chemical terms

proline, isoleucine, alcohol, leucine, arginine, Alcohol

Organisms

rat, Rats, rats

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS2688.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0009058",
    "https://identifiers.org/GO:0008152"
  ],
  "go_kw": [
    "biosynthesis",
    "metabolism"
  ],
  "integmet_study": "MTBLS2688",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D011392",
    "https://identifiers.org/mesh:D007532",
    "https://identifiers.org/mesh:D000438",
    "https://identifiers.org/mesh:D007930",
    "https://identifiers.org/mesh:D001120"
  ],
  "mesh_chemical_pubtator_kw": [
    "proline",
    "isoleucine",
    "alcohol",
    "leucine",
    "arginine",
    "Alcohol"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D000437",
    "https://identifiers.org/mesh:D001523",
    "https://identifiers.org/mesh:D009358",
    "https://identifiers.org/mesh:D020270",
    "https://identifiers.org/mesh:D064806",
    "https://identifiers.org/mesh:C535298"
  ],
  "mesh_disease_pubtator_kw": [
    "alcohol abuse",
    "psychiatric disorders",
    "neurotransmitter disorders",
    "Alcohol Withdrawal Syndrome",
    "microbiota dysbiosis",
    "alcoholism",
    "gut leakiness",
    "alcohol dependence"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:10116"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "rat",
    "Rats",
    "rats"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS2688",
  "study_findings": "Alcohol alters gut microbiota, increases permeability, affects serum metabolites and neurotransmitter homeostasis.",
  "study_observation": "Gut microbiota, intestinal permeability, serum metabolic profile in alcohol-dependent rats.",
  "study_summary": "Alcohol affects gut microbiota and serum metabolites.",
  "study_title_original": "Integrated Analyses of the Gut Microbiota, Intestinal Permeability and Serum Metabolome Phenotype in Rats with Alcohol Withdrawal Syndrome"
}