Gut Microbiota Dysbiosis is Associated with Altered Bile Acid Metabolism in Infantile Cholestasis

Study details

Source ID

https://identifiers.org/metabolights:MTBLS1295

Title

Gut Microbiota Dysbiosis is Associated with Altered Bile Acid Metabolism in Infantile Cholestasis

Summary

Gut microbiota dysbiosis affects bile acid metabolism.

Observation

Gut microbiota composition and bile acid levels in CJ infants

Findings

CJ infants have altered gut microbiota and reduced fecal bile acids.

Disease terms

liver diseases, cholestatic jaundice, CJ, Gut Microbiota Dysbiosis, gut microbiota dysbiosis, Cholestasis, impaired liver function

Gene terms

—

Chemical terms

chenodeoxycholic acid, Bile Acid, deoxycholic acid, DCA, cholic acid, BAs, bile acid, CDCA, BA

Organisms

human, Veillonella, infants, Bifidobacterium, Streptococcus, Clostridium, Faecalibacterium prausnitzii, Gemella

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS1295.

{
  "@type": "Dataset",
  "integmet_study": "MTBLS1295",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D002635",
    "https://identifiers.org/mesh:D001647",
    "https://identifiers.org/mesh:D003840",
    "https://identifiers.org/mesh:D019826",
    "https://identifiers.org/mesh:D001464"
  ],
  "mesh_chemical_pubtator_kw": [
    "chenodeoxycholic acid",
    "Bile Acid",
    "deoxycholic acid",
    "DCA",
    "cholic acid",
    "BAs",
    "bile acid",
    "CDCA",
    "BA"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D008107",
    "https://identifiers.org/mesh:D041781",
    "https://identifiers.org/mesh:D064806",
    "https://identifiers.org/mesh:D002779"
  ],
  "mesh_disease_pubtator_kw": [
    "liver diseases",
    "cholestatic jaundice",
    "CJ",
    "Gut Microbiota Dysbiosis",
    "gut microbiota dysbiosis",
    "Cholestasis",
    "impaired liver function"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:9606",
    "https://identifiers.org/taxonomy:29465",
    "https://identifiers.org/taxonomy:1678",
    "https://identifiers.org/taxonomy:1301",
    "https://identifiers.org/taxonomy:1485",
    "https://identifiers.org/taxonomy:853",
    "https://identifiers.org/taxonomy:1378"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "human",
    "Veillonella",
    "infants",
    "Bifidobacterium",
    "Streptococcus",
    "Clostridium",
    "Faecalibacterium prausnitzii",
    "Gemella"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS1295",
  "study_findings": "CJ infants have altered gut microbiota and reduced fecal bile acids.",
  "study_observation": "Gut microbiota composition and bile acid levels in CJ infants",
  "study_summary": "Gut microbiota dysbiosis affects bile acid metabolism.",
  "study_title_original": "Gut Microbiota Dysbiosis is Associated with Altered Bile Acid Metabolism in Infantile Cholestasis"
}