Diff Profiles › MTBLS4223_0001_00000001

Wild_Type_vs_Gene_Knockdown

Wild_Type vs Gene_Knockdown

p-value ≤ 0.05 12 significant 2025-09-26 00:00:00 Study: MTBLS4223
28 Total Features
12 Significant
0.05 p-value Threshold

Profile details

Identifier
MTBLS4223_0001_00000001
Linked study
MTBLS4223 — The functional role of OGDH for maintaining mitochondrial respiration and identity of primed human embryonic stem cells
Comparison
Wild_Type vs Gene_Knockdown
Group A
Wild type hESCs serving as the control group.. Provides a reference point to assess the impact of gene knockdown on hESCs.
Group B
hESCs with OGDH gene knockdown.. Key to understanding the role of OGDH in mitochondrial respiration and pluripotency maintenance in hESCs.
Total features tested
28
Significant features
12
p-value threshold
0.05
Ratio threshold (upper)
1.5
Ratio threshold (lower)
1/1.5
Date created
2025-09-26 00:00:00

Top hits

Metabolite ID (InChI Key) Name Direction Ratio p-value
BJEPYKJPYRNKOW-REOHCLBHSA-N <small>L</small>-malic acid up 7.472 1.62e-12
VZCYOOQTPOCHFL-OWOJBTEDSA-N (2<i>E</i>)-2-butenedioic acid up 4.249 5.2e-09
UDMBCSSLTHHNCD-KQYNXXCUSA-N Adenosine-5'-monophosphoric acid down 0.2433 7.35e-08
ZKHQWZAMYRWXGA-KQYNXXCUSA-N Adenosine 5'-triphosphate up 2.947 7.89e-09
RQFCJASXJCIDSX-UUOKFMHZSA-N GMP down 0.3701 1.05e-06
QGWNDRXFNXRZMB-UUOKFMHZSA-N Guanosine diphosphate down 0.4449 1.24e-06
GTZCVFVGUGFEME-IWQZZHSRSA-N <i>cis</i>-1-propene-1,2,3-tricarboxylic acid up 1.9 8.85e-08
RNBGYGVWRKECFJ-ARQDHWQXSA-N BETA FRUCTOSE 1,6-DIPHOSPHATE down 0.4791 8.54e-07
KPGXRSRHYNQIFN-UHFFFAOYSA-N α-ketoglutaric acid down 0.3406 0.000248
BGWGXPAPYGQALX-ARQDHWQXSA-N 6-<em>O</em>-phosphono-β-<small>D</small>-fructofuranose down 0.5696 6.32e-05